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Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size.
Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein D, Gross RW. Moon SH, et al. Among authors: sims hf. J Biol Chem. 2016 Sep 9;291(37):19687-700. doi: 10.1074/jbc.M116.740597. Epub 2016 Jul 23. J Biol Chem. 2016. PMID: 27453526 Free PMC article.
The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.
Yan W, Jenkins CM, Han X, Mancuso DJ, Sims HF, Yang K, Gross RW. Yan W, et al. Among authors: sims hf. J Biol Chem. 2005 Jul 22;280(29):26669-79. doi: 10.1074/jbc.M502358200. Epub 2005 May 20. J Biol Chem. 2005. PMID: 15908428 Free article.
Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
Mancuso DJ, Han X, Jenkins CM, Lehman JJ, Sambandam N, Sims HF, Yang J, Yan W, Yang K, Green K, Abendschein DR, Saffitz JE, Gross RW. Mancuso DJ, et al. Among authors: sims hf. J Biol Chem. 2007 Mar 23;282(12):9216-27. doi: 10.1074/jbc.M607307200. Epub 2007 Jan 9. J Biol Chem. 2007. PMID: 17213206 Free article.
Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
Mancuso DJ, Sims HF, Han X, Jenkins CM, Guan SP, Yang K, Moon SH, Pietka T, Abumrad NA, Schlesinger PH, Gross RW. Mancuso DJ, et al. Among authors: sims hf. J Biol Chem. 2007 Nov 30;282(48):34611-22. doi: 10.1074/jbc.M707795200. Epub 2007 Oct 8. J Biol Chem. 2007. PMID: 17923475 Free PMC article.
Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.
Mancuso DJ, Kotzbauer P, Wozniak DF, Sims HF, Jenkins CM, Guan S, Han X, Yang K, Sun G, Malik I, Conyers S, Green KG, Schmidt RE, Gross RW. Mancuso DJ, et al. Among authors: sims hf. J Biol Chem. 2009 Dec 18;284(51):35632-44. doi: 10.1074/jbc.M109.055194. J Biol Chem. 2009. PMID: 19840936 Free PMC article.
Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
Mancuso DJ, Sims HF, Yang K, Kiebish MA, Su X, Jenkins CM, Guan S, Moon SH, Pietka T, Nassir F, Schappe T, Moore K, Han X, Abumrad NA, Gross RW. Mancuso DJ, et al. Among authors: sims hf. J Biol Chem. 2010 Nov 19;285(47):36495-510. doi: 10.1074/jbc.M110.115766. Epub 2010 Sep 3. J Biol Chem. 2010. PMID: 20817734 Free PMC article.
59 results