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Page 1
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.
Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS. Shibata S, et al. Among authors: napuli aj. Antimicrob Agents Chemother. 2011 May;55(5):1982-9. doi: 10.1128/AAC.01796-10. Epub 2011 Jan 31. Antimicrob Agents Chemother. 2011. PMID: 21282428 Free PMC article.
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.
Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC. Ojo KK, et al. Among authors: napuli aj. Antimicrob Agents Chemother. 2008 Oct;52(10):3710-7. doi: 10.1128/AAC.00364-08. Epub 2008 Jul 21. Antimicrob Agents Chemother. 2008. PMID: 18644955 Free PMC article.
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: napuli aj. J Mol Biol. 2010 Mar 26;397(2):481-94. doi: 10.1016/j.jmb.2010.01.051. Epub 2010 Feb 2. J Mol Biol. 2010. PMID: 20132829 Free PMC article.
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.
Ojo KK, Arakaki TL, Napuli AJ, Inampudi KK, Keyloun KR, Zhang L, Hol WG, Verlinde CL, Merritt EA, Van Voorhis WC. Ojo KK, et al. Among authors: napuli aj. Mol Biochem Parasitol. 2011 Apr;176(2):98-108. doi: 10.1016/j.molbiopara.2010.12.009. Epub 2010 Dec 30. Mol Biochem Parasitol. 2011. PMID: 21195115 Free PMC article.
Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.
Merritt EA, Arakaki TL, Gillespie R, Napuli AJ, Kim JE, Buckner FS, Van Voorhis WC, Verlinde CL, Fan E, Zucker F, Hol WG. Merritt EA, et al. Among authors: napuli aj. Mol Biochem Parasitol. 2011 May;177(1):20-8. doi: 10.1016/j.molbiopara.2011.01.003. Epub 2011 Jan 19. Mol Biochem Parasitol. 2011. PMID: 21255615 Free PMC article.
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: napuli aj. Mol Biochem Parasitol. 2010 Feb;169(2):95-100. doi: 10.1016/j.molbiopara.2009.10.005. Epub 2009 Oct 27. Mol Biochem Parasitol. 2010. PMID: 19874856 Free PMC article.
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA. Larson ET, et al. Among authors: napuli aj. J Mol Biol. 2010 Mar 12;396(5):1244-59. doi: 10.1016/j.jmb.2010.01.013. Epub 2010 Jan 11. J Mol Biol. 2010. PMID: 20070944 Free PMC article.
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, Hol WG, Merritt EA, Van Voorhis WC. Ojo KK, et al. Among authors: napuli aj. Nat Struct Mol Biol. 2010 May;17(5):602-7. doi: 10.1038/nsmb.1818. Epub 2010 May 2. Nat Struct Mol Biol. 2010. PMID: 20436472 Free PMC article.
40 results