Zhu H - Search Results

1

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Nakagawa-Goto K, Wu PC, Lai CY, Hamel E, Zhu H, Zhang L, Kozaka T, Ohkoshi E, Goto M, Bastow KF, Lee KH. Nakagawa-Goto K, et al. Among authors: zhu h. J Med Chem. 2011 Mar 10;54(5):1244-55. doi: 10.1021/jm1011947. Epub 2011 Feb 1. J Med Chem. 2011. PMID: 21284385 Free PMC article.

2

Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues.

Nakagawa-Goto K, Chang PC, Lai CY, Hung HY, Chen TH, Wu PC, Zhu H, Sedykh A, Bastow KF, Lee KH. Nakagawa-Goto K, et al. Among authors: zhu h. J Med Chem. 2010 Sep 23;53(18):6699-705. doi: 10.1021/jm100846r. J Med Chem. 2010. PMID: 20735140 Free PMC article.

3

Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents.

Ye D, Shi Q, Leung CH, Kim SW, Park SY, Gullen EA, Jiang ZL, Zhu H, Morris-Natschke SL, Cheng YC, Lee KH. Ye D, et al. Among authors: zhu h. Bioorg Med Chem. 2012 Jul 15;20(14):4489-94. doi: 10.1016/j.bmc.2012.05.030. Epub 2012 May 19. Bioorg Med Chem. 2012. PMID: 22698783 Free PMC article.

4

Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.

Zhou T, Shi Q, Chen CH, Zhu H, Huang L, Ho P, Lee KH. Zhou T, et al. Among authors: zhu h. Bioorg Med Chem. 2010 Sep 15;18(18):6678-89. doi: 10.1016/j.bmc.2010.07.065. Epub 2010 Aug 2. Bioorg Med Chem. 2010. PMID: 20728367 Free PMC article.

5

Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity.

Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A. Sedykh A, et al. Among authors: zhu h. Environ Health Perspect. 2011 Mar;119(3):364-70. doi: 10.1289/ehp.1002476. Epub 2010 Oct 27. Environ Health Perspect. 2011. PMID: 20980217 Free PMC article.

6

QSAR modeling of the blood-brain barrier permeability for diverse organic compounds.

Zhang L, Zhu H, Oprea TI, Golbraikh A, Tropsha A. Zhang L, et al. Among authors: zhu h. Pharm Res. 2008 Aug;25(8):1902-14. doi: 10.1007/s11095-008-9609-0. Epub 2008 Jun 14. Pharm Res. 2008. PMID: 18553217

7

Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.

Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A. Zhang L, et al. Among authors: zhu h. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):67-76. doi: 10.1016/j.taap.2013.04.032. Epub 2013 May 23. Toxicol Appl Pharmacol. 2013. PMID: 23707773 Free PMC article.

8

Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers.

Sprague B, Shi Q, Kim MT, Zhang L, Sedykh A, Ichiishi E, Tokuda H, Lee KH, Zhu H. Sprague B, et al. Among authors: zhu h. J Comput Aided Mol Des. 2014 Jun;28(6):631-46. doi: 10.1007/s10822-014-9748-9. Epub 2014 May 20. J Comput Aided Mol Des. 2014. PMID: 24840854 Free PMC article.

9

Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening.

Zhang L, Fourches D, Sedykh A, Zhu H, Golbraikh A, Ekins S, Clark J, Connelly MC, Sigal M, Hodges D, Guiguemde A, Guy RK, Tropsha A. Zhang L, et al. Among authors: zhu h. J Chem Inf Model. 2013 Feb 25;53(2):475-92. doi: 10.1021/ci300421n. Epub 2013 Jan 23. J Chem Inf Model. 2013. PMID: 23252936 Free PMC article.

10

Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimization libraries.

Liu Y, Li F, Wu L, Wang W, Zhu H, Zhang Q, Zhou H, Yan B. Liu Y, et al. Among authors: zhu h. Bioorg Med Chem Lett. 2015 May 1;25(9):1971-5. doi: 10.1016/j.bmcl.2015.03.016. Epub 2015 Mar 14. Bioorg Med Chem Lett. 2015. PMID: 25827524 Free PMC article.

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