Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR.
Bayascas JR, et al. Among authors: sakamoto k.
Mol Cell Biol. 2008 May;28(10):3258-72. doi: 10.1128/MCB.02032-07. Epub 2008 Mar 17.
Mol Cell Biol. 2008.
PMID: 18347057
Free PMC article.