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Page 1
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG. Costantini DL, et al. Among authors: backx ph. Cell. 2005 Oct 21;123(2):347-58. doi: 10.1016/j.cell.2005.08.004. Cell. 2005. PMID: 16239150 Free PMC article.
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.
Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO. Bousette N, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6. doi: 10.1073/pnas.1013555107. Epub 2010 Oct 11. Proc Natl Acad Sci U S A. 2010. PMID: 20937869 Free PMC article.
The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy.
Martino TA, Tata N, Simpson JA, Vanderlaan R, Dawood F, Kabir MG, Khaper N, Cifelli C, Podobed P, Liu PP, Husain M, Heximer S, Backx PH, Sole MJ. Martino TA, et al. Among authors: backx ph. J Am Coll Cardiol. 2011 May 17;57(20):2020-8. doi: 10.1016/j.jacc.2010.11.022. J Am Coll Cardiol. 2011. PMID: 21565639 Free article.
Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.
Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Rose RA, et al. Among authors: backx ph. Circ Arrhythm Electrophysiol. 2011 Oct;4(5):733-42. doi: 10.1161/CIRCEP.110.960401. Epub 2011 Jul 11. Circ Arrhythm Electrophysiol. 2011. PMID: 21747058 Free PMC article.
Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones P, Tian X, Wilson LS, Ahmad F, Chen SRW, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. Beca S, et al. Among authors: backx ph. Circ Res. 2011 Oct 14;109(9):1024-1030. doi: 10.1161/CIRCRESAHA.111.250464. Epub 2011 Sep 8. Circ Res. 2011. PMID: 21903937 Free PMC article.
Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.
Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, Keating A, Li RK, Nahrendorf M, Geisslinger G, Backx PH, Rubin BB. Degousee N, et al. Among authors: backx ph. Circulation. 2012 Jun 12;125(23):2904-13. doi: 10.1161/CIRCULATIONAHA.112.099754. Epub 2012 May 15. Circulation. 2012. PMID: 22589381
228 results