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Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.
Ressler KJ, Mercer KB, Bradley B, Jovanovic T, Mahan A, Kerley K, Norrholm SD, Kilaru V, Smith AK, Myers AJ, Ramirez M, Engel A, Hammack SE, Toufexis D, Braas KM, Binder EB, May V. Ressler KJ, et al. Among authors: braas km. Nature. 2011 Feb 24;470(7335):492-7. doi: 10.1038/nature09856. Nature. 2011. PMID: 21350482 Free PMC article.
Roles for pituitary adenylate cyclase-activating peptide (PACAP) expression and signaling in the bed nucleus of the stria terminalis (BNST) in mediating the behavioral consequences of chronic stress.
Hammack SE, Roman CW, Lezak KR, Kocho-Shellenberg M, Grimmig B, Falls WA, Braas K, May V. Hammack SE, et al. J Mol Neurosci. 2010 Nov;42(3):327-40. doi: 10.1007/s12031-010-9364-7. Epub 2010 Apr 20. J Mol Neurosci. 2010. PMID: 20405238 Free PMC article. Review.
Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior.
Hammack SE, Cheung J, Rhodes KM, Schutz KC, Falls WA, Braas KM, May V. Hammack SE, et al. Among authors: braas km. Psychoneuroendocrinology. 2009 Jul;34(6):833-43. doi: 10.1016/j.psyneuen.2008.12.013. Epub 2009 Jan 31. Psychoneuroendocrinology. 2009. PMID: 19181454 Free PMC article.
PACAP in the BNST produces anorexia and weight loss in male and female rats.
Kocho-Schellenberg M, Lezak KR, Harris OM, Roelke E, Gick N, Choi I, Edwards S, Wasserman E, Toufexis DJ, Braas KM, May V, Hammack SE. Kocho-Schellenberg M, et al. Among authors: braas km. Neuropsychopharmacology. 2014 Jun;39(7):1614-23. doi: 10.1038/npp.2014.8. Epub 2014 Jan 17. Neuropsychopharmacology. 2014. PMID: 24434744 Free PMC article.
68 results