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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, Barbieri LR, Ding WD, Krishnamurthy G, Hu YB, Lucas J, Bernan VS, Cai P, Levin JI, Mansour TS, Gibbons JJ, Abraham RT, Yu K. Toral-Barza L, et al. Mol Cancer Ther. 2007 Nov;6(11):3028-38. doi: 10.1158/1535-7163.MCT-07-0211. Epub 2007 Nov 7. Mol Cancer Ther. 2007. PMID: 17989320
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.
Kim KH, Wissner A, Floyd MB Jr, Fraser HL, Wang YD, Dushin RG, Hu Y, Olland A, Guo B, Arndt K. Kim KH, et al. Among authors: hu y. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5225-8. doi: 10.1016/j.bmcl.2009.07.007. Epub 2009 Jul 8. Bioorg Med Chem Lett. 2009. PMID: 19628388
Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Wang X, Berger DM, Salaski EJ, Torres N, Hu Y, Levin JI, Powell D, Wojciechowicz D, Collins K, Frommer E. Wang X, et al. Among authors: hu y. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6571-4. doi: 10.1016/j.bmcl.2009.10.030. Epub 2009 Oct 13. Bioorg Med Chem Lett. 2009. PMID: 19854649
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Berger DM, Torres N, Dutia M, Powell D, Ciszewski G, Gopalsamy A, Levin JI, Kim KH, Xu W, Wilhelm J, Hu Y, Collins K, Feldberg L, Kim S, Frommer E, Wojciechowicz D, Mallon R. Berger DM, et al. Among authors: hu y. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. doi: 10.1016/j.bmcl.2009.10.049. Epub 2009 Oct 26. Bioorg Med Chem Lett. 2009. PMID: 19864136
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.
Di Grandi MJ, Berger DM, Hopper DW, Zhang C, Dutia M, Dunnick AL, Torres N, Levin JI, Diamantidis G, Zapf CW, Bloom JD, Hu Y, Powell D, Wojciechowicz D, Collins K, Frommer E. Di Grandi MJ, et al. Among authors: hu y. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6957-61. doi: 10.1016/j.bmcl.2009.10.058. Epub 2009 Oct 28. Bioorg Med Chem Lett. 2009. PMID: 19875283
47,036 results
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