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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Zapf CW, Bloom JD, McBean JL, Dushin RG, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Levin JI. Zapf CW, et al. Among authors: mcbean jl. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3627-31. doi: 10.1016/j.bmcl.2011.04.102. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21605975