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Page 1
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.
Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Ingalls C, Sutherland AG, Sonye JP, Eid CN, Golas J, Liu H, Boschelli F, Hu Y, Vogan E, Levin JI. Zapf CW, et al. Among authors: sutherland ag. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2278-82. doi: 10.1016/j.bmcl.2011.02.101. Epub 2011 Feb 28. Bioorg Med Chem Lett. 2011. PMID: 21420297
Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.
Dushin RG, Wang TZ, Sum PE, He H, Sutherland AG, Ashcroft JS, Graziani EI, Koehn FE, Bradford PA, Petersen PJ, Wheless KL, How D, Torres N, Lenoy EB, Weiss WJ, Lang SA, Projan SJ, Shlaes DM, Mansour TS. Dushin RG, et al. Among authors: sutherland ag. J Med Chem. 2004 Jul 1;47(14):3487-90. doi: 10.1021/jm049765y. J Med Chem. 2004. PMID: 15214775
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Kincaid SL, Sukhdeo MN, Sutherland AG, Ding W, Kenny CH, Sabus CL, Liu H, Dushin EG, Moghazeh SL, Labthavikul P, Petersen PJ, Tuckman M, Haney SA, Ruzin AV. Jennings LD, et al. Among authors: sutherland ag. Bioorg Med Chem. 2004 Oct 1;12(19):5115-31. doi: 10.1016/j.bmc.2004.07.031. Bioorg Med Chem. 2004. PMID: 15351395
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.
Ruzin A, Singh G, Severin A, Yang Y, Dushin RG, Sutherland AG, Minnick A, Greenstein M, May MK, Shlaes DM, Bradford PA. Ruzin A, et al. Among authors: sutherland ag. Antimicrob Agents Chemother. 2004 Mar;48(3):728-38. doi: 10.1128/AAC.48.3.728-738.2004. Antimicrob Agents Chemother. 2004. PMID: 14982757 Free PMC article.
Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders.
Cirillo PF, Asojo OA, Khire U, Lee Y, Mootien S, Hegan P, Sutherland AG, Peterson-Roth E, Ledizet M, Koski RA, Anthony KG. Cirillo PF, et al. Among authors: sutherland ag. ACS Med Chem Lett. 2019 Nov 19;11(10):1843-1847. doi: 10.1021/acsmedchemlett.9b00351. eCollection 2020 Oct 8. ACS Med Chem Lett. 2019. PMID: 33062162 Free PMC article.
65 results