Vogan E - Search Results

1

Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.

Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Ingalls C, Sutherland AG, Sonye JP, Eid CN, Golas J, Liu H, Boschelli F, Hu Y, Vogan E, Levin JI. Zapf CW, et al. Among authors: vogan e. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2278-82. doi: 10.1016/j.bmcl.2011.02.101. Epub 2011 Feb 28. Bioorg Med Chem Lett. 2011. PMID: 21420297

2

Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F. Gopalsamy A, et al. Among authors: vogan e. J Med Chem. 2008 Feb 14;51(3):373-5. doi: 10.1021/jm701385c. Epub 2008 Jan 16. J Med Chem. 2008. PMID: 18197612

3

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.

Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Otteng M, Ingalls C, Golas JM, Liu H, Lucas J, Boschelli F, Hu Y, Vogan E, Levin JI. Zapf CW, et al. Among authors: vogan e. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3411-6. doi: 10.1016/j.bmcl.2011.03.112. Epub 2011 Apr 5. Bioorg Med Chem Lett. 2011. PMID: 21515049

4

Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.

Zapf CW, Bloom JD, McBean JL, Dushin RG, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Levin JI. Zapf CW, et al. Among authors: vogan e. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3627-31. doi: 10.1016/j.bmcl.2011.04.102. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21605975

5

Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.

Zapf CW, Bloom JD, Li Z, Dushin RG, Nittoli T, Otteng M, Nikitenko A, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Olland A, Johnson M, Levin JI. Zapf CW, et al. Among authors: vogan e. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4602-7. doi: 10.1016/j.bmcl.2011.05.102. Epub 2011 Jun 27. Bioorg Med Chem Lett. 2011. PMID: 21715165

6

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.

Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan J. Wang Q, et al. Among authors: vogan em. Elife. 2015 Feb 20;4:e06074. doi: 10.7554/eLife.06074. Elife. 2015. PMID: 25699547 Free PMC article.

7

Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.

Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC. Chen B, et al. Structure. 2005 Feb;13(2):197-211. doi: 10.1016/j.str.2004.12.004. Structure. 2005. PMID: 15698564 Free article.

8

Structure of an unliganded simian immunodeficiency virus gp120 core.

Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC. Chen B, et al. Nature. 2005 Feb 24;433(7028):834-41. doi: 10.1038/nature03327. Nature. 2005. PMID: 15729334

9

Shikimate dehydrogenase structure reveals novel fold.

Vogan E. Vogan E. Structure. 2003 Aug;11(8):902-3. doi: 10.1016/s0969-2126(03)00165-5. Structure. 2003. PMID: 12906820 Free article.

10

Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis.

Vogan EM, Bellamacina C, He X, Liu HW, Ringe D, Petsko GA. Vogan EM, et al. Biochemistry. 2004 Mar 23;43(11):3057-67. doi: 10.1021/bi035547f. Biochemistry. 2004. PMID: 15023057

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