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Page 1
Inflammasome is a central player in the induction of obesity and insulin resistance.
Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D, Neale GA, Hooiveld GJ, Hijmans A, Vroegrijk I, van den Berg S, Romijn J, Rensen PC, Joosten LA, Netea MG, Kanneganti TD. Stienstra R, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15324-9. doi: 10.1073/pnas.1100255108. Epub 2011 Aug 29. Proc Natl Acad Sci U S A. 2011. PMID: 21876127 Free PMC article.
Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion.
van Diepen JA, Stienstra R, Vroegrijk IO, van den Berg SA, Salvatori D, Hooiveld GJ, Kersten S, Tack CJ, Netea MG, Smit JW, Joosten LA, Havekes LM, van Dijk KW, Rensen PC. van Diepen JA, et al. Among authors: vroegrijk io. J Lipid Res. 2013 Feb;54(2):448-56. doi: 10.1194/jlr.M031963. Epub 2012 Nov 17. J Lipid Res. 2013. PMID: 23160218 Free PMC article.
CD36 is important for adipocyte recruitment and affects lipolysis.
Vroegrijk IO, van Klinken JB, van Diepen JA, van den Berg SA, Febbraio M, Steinbusch LK, Glatz JF, Havekes LM, Voshol PJ, Rensen PC, van Dijk KW, van Harmelen V. Vroegrijk IO, et al. Obesity (Silver Spring). 2013 Oct;21(10):2037-45. doi: 10.1002/oby.20354. Epub 2013 May 29. Obesity (Silver Spring). 2013. PMID: 23512311 Free article.
Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice.
Declercq J, Kumar A, Van Diepen JA, Vroegrijk IO, Gysemans C, Di Pietro C, Voshol PJ, Mathieu C, Ectors N, Van de Ven WJ, Verfaillie CM. Declercq J, et al. Among authors: vroegrijk io. Diabetes. 2010 Aug;59(8):1957-65. doi: 10.2337/db09-1446. Epub 2010 Jun 3. Diabetes. 2010. PMID: 20522588 Free PMC article.
Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice.
Steinbusch LK, Luiken JJ, Vlasblom R, Chabowski A, Hoebers NT, Coumans WA, Vroegrijk IO, Voshol PJ, Ouwens DM, Glatz JF, Diamant M. Steinbusch LK, et al. Among authors: vroegrijk io. Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E618-27. doi: 10.1152/ajpendo.00106.2011. Epub 2011 Jun 28. Am J Physiol Endocrinol Metab. 2011. PMID: 21712535 Free article.
FcRγ-chain deficiency reduces the development of diet-induced obesity.
van Beek L, Vroegrijk IO, Katiraei S, Heemskerk MM, van Dam AD, Kooijman S, Rensen PC, Koning F, Verbeek JS, Willems van Dijk K, van Harmelen V. van Beek L, et al. Among authors: vroegrijk io. Obesity (Silver Spring). 2015 Dec;23(12):2435-44. doi: 10.1002/oby.21309. Epub 2015 Nov 2. Obesity (Silver Spring). 2015. PMID: 26523352 Free article.
Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo.
Fonager J, Pasini EM, Braks JA, Klop O, Ramesar J, Remarque EJ, Vroegrijk IO, van Duinen SG, Thomas AW, Khan SM, Mann M, Kocken CH, Janse CJ, Franke-Fayard BM. Fonager J, et al. Among authors: vroegrijk io. J Exp Med. 2012 Jan 16;209(1):93-107. doi: 10.1084/jem.20110762. Epub 2011 Dec 19. J Exp Med. 2012. PMID: 22184632 Free PMC article.
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