Smit AB - Search Results

1

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors.

Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C. Brams M, et al. Among authors: smit ab. PLoS Biol. 2011 Mar;9(3):e1001034. doi: 10.1371/journal.pbio.1001034. Epub 2011 Mar 29. PLoS Biol. 2011. PMID: 21468359 Free PMC article.

2

Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein.

Brams M, Gay EA, Sáez JC, Guskov A, van Elk R, van der Schors RC, Peigneur S, Tytgat J, Strelkov SV, Smit AB, Yakel JL, Ulens C. Brams M, et al. Among authors: smit ab. J Biol Chem. 2011 Feb 11;286(6):4420-8. doi: 10.1074/jbc.M110.188730. Epub 2010 Nov 29. J Biol Chem. 2011. PMID: 21115477 Free PMC article.

3

Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein.

Billen B, Spurny R, Brams M, van Elk R, Valera-Kummer S, Yakel JL, Voets T, Bertrand D, Smit AB, Ulens C. Billen B, et al. Among authors: smit ab. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9173-8. doi: 10.1073/pnas.1116397109. Epub 2012 May 22. Proc Natl Acad Sci U S A. 2012. PMID: 22619328 Free PMC article.

4

Structural basis of ligand recognition in 5-HT3 receptors.

Kesters D, Thompson AJ, Brams M, van Elk R, Spurny R, Geitmann M, Villalgordo JM, Guskov A, Danielson UH, Lummis SC, Smit AB, Ulens C. Kesters D, et al. Among authors: smit ab. EMBO Rep. 2013 Jan;14(1):49-56. doi: 10.1038/embor.2012.189. Epub 2012 Nov 30. EMBO Rep. 2013. PMID: 23196367 Free PMC article.

5

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

Ulens C, Hogg RC, Celie PH, Bertrand D, Tsetlin V, Smit AB, Sixma TK. Ulens C, et al. Among authors: smit ab. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3615-20. doi: 10.1073/pnas.0507889103. Epub 2006 Feb 27. Proc Natl Acad Sci U S A. 2006. PMID: 16505382 Free PMC article.

6

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.

Otvos RA, Iyer JK, van Elk R, Ulens C, Niessen WM, Somsen GW, Kini RM, Smit AB, Kool J. Otvos RA, et al. Among authors: smit ab. Toxins (Basel). 2015 Jun 24;7(7):2336-53. doi: 10.3390/toxins7072336. Toxins (Basel). 2015. PMID: 26114334 Free PMC article.

7

Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors.

Smit AB, Celie PH, Kasheverov IE, Mordvintsev DY, van Nierop P, Bertrand D, Tsetlin V, Sixma TK. Smit AB, et al. J Mol Neurosci. 2006;30(1-2):9-10. doi: 10.1385/JMN:30:1:9. J Mol Neurosci. 2006. PMID: 17192605

8

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.

Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ. Dutertre S, et al. Among authors: smit ab. EMBO J. 2007 Aug 22;26(16):3858-67. doi: 10.1038/sj.emboj.7601785. Epub 2007 Jul 26. EMBO J. 2007. PMID: 17660751 Free PMC article.

9

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ. Ulens C, et al. Among authors: smit ab. J Med Chem. 2009 Apr 23;52(8):2372-83. doi: 10.1021/jm801400g. J Med Chem. 2009. PMID: 19331415

10

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

Celie PH, Kasheverov IE, Mordvintsev DY, Hogg RC, van Nierop P, van Elk R, van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB. Celie PH, et al. Among authors: smit ab. Nat Struct Mol Biol. 2005 Jul;12(7):582-8. doi: 10.1038/nsmb951. Epub 2005 Jun 12. Nat Struct Mol Biol. 2005. PMID: 15951818

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