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Page 1
Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 1.
Matasi JJ, Brumfield S, Tulshian D, Czarnecki M, Greenlee W, Garlisi CG, Qiu H, Devito K, Chen SC, Sun Y, Bertorelli R, Geiss W, Le VD, Martin GS, Vellekoop SA, Haber J, Allard ML. Matasi JJ, et al. Among authors: haber j. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3805-8. doi: 10.1016/j.bmcl.2011.04.034. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21570840
Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2.
Brumfield S, Matasi JJ, Tulshian D, Czarniecki M, Greenlee W, Garlisi C, Qiu H, Devito K, Chen SC, Sun Y, Bertorelli R, Ansell J, Geiss W, Le VD, Martin GS, Vellekoop SA, Haber J, Allard ML. Brumfield S, et al. Among authors: haber j. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7287-90. doi: 10.1016/j.bmcl.2011.10.037. Epub 2011 Oct 21. Bioorg Med Chem Lett. 2011. PMID: 22078214
Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
Wityak J, McGee KF, Conlon MP, Song RH, Duffy BC, Clayton B, Lynch M, Wang G, Freeman E, Haber J, Kitchen DB, Manning DD, Ismail J, Khmelnitsky Y, Michels P, Webster J, Irigoyen M, Luche M, Hultman M, Bai M, Kuok ID, Newell R, Lamers M, Leonard P, Yates D, Matthews K, Ongeri L, Clifton S, Mead T, Deupree S, Wheelan P, Lyons K, Wilson C, Kiselyov A, Toledo-Sherman L, Beconi M, Muñoz-Sanjuan I, Bard J, Dominguez C. Wityak J, et al. Among authors: haber j. J Med Chem. 2015 Apr 9;58(7):2967-87. doi: 10.1021/jm5013598. Epub 2015 Mar 19. J Med Chem. 2015. PMID: 25760409
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
Liu L, Johnson PD, Prime ME, Khetarpal V, Lee MR, Brown CJ, Chen X, Clark-Frew D, Coe S, Conlon M, Davis R, Ensor S, Esposito S, Moren AF, Gai X, Green S, Greenaway C, Haber J, Halldin C, Hayes S, Herbst T, Herrmann F, Heßmann M, Hsai MM, Kotey A, Mangette JE, Mills MR, Monteagudo E, Nag S, Nibbio M, Orsatti L, Schaertl S, Scheich C, Sproston J, Stepanov V, Varnäs K, Varrone A, Wityak J, Mrzljak L, Munoz-Sanjuan I, Bard JA, Dominguez C. Liu L, et al. Among authors: haber j. J Med Chem. 2021 Aug 26;64(16):12003-12021. doi: 10.1021/acs.jmedchem.1c00667. Epub 2021 Aug 5. J Med Chem. 2021. PMID: 34351166
719 results