Humes JL - Search Results

1

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo.

Carter RI, Mumford RA, Treonze KM, Finke PE, Davies P, Si Q, Humes JL, Dirksen A, Piitulainen E, Ahmad A, Stockley RA. Carter RI, et al. Among authors: humes jl. Thorax. 2011 Aug;66(8):686-91. doi: 10.1136/thx.2010.154690. Epub 2011 May 26. Thorax. 2011. PMID: 21617168 Clinical Trial.

2

Formation of polymorphonuclear leukocyte elastase: alpha 1 proteinase inhibitor complex and A alpha (1-21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187. A model to characterize inhibitors of polymorphonuclear leukocyte elastase.

Pacholok SG, Davies P, Dorn C, Finke P, Hanlon WA, Mumford RA, Humes JL. Pacholok SG, et al. Among authors: humes jl. Biochem Pharmacol. 1995 May 17;49(10):1513-20. doi: 10.1016/0006-2952(95)00031-t. Biochem Pharmacol. 1995. PMID: 7763294

3

Inhibition of neutrophil elastase in CF sputum by L-658,758.

Rees DD, Brain JD, Wohl ME, Humes JL, Mumford RA. Rees DD, et al. Among authors: humes jl. J Pharmacol Exp Ther. 1997 Dec;283(3):1201-6. J Pharmacol Exp Ther. 1997. PMID: 9399994

4

rTNF alpha facilitates human polymorphonuclear leukocyte adherence to fibrinogen matrices with mobilization of specific and tertiary but not azurophilic granule markers.

Hanlon WA, Stolk J, Davies P, Humes JL, Mumford R, Bonney RJ. Hanlon WA, et al. Among authors: humes jl. J Leukoc Biol. 1991 Jul;50(1):43-8. doi: 10.1002/jlb.50.1.43. J Leukoc Biol. 1991. PMID: 1647433

5

The discovery and biologic properties of cephalosporin-based inhibitors of PMN elastase.

Davies P, Ashe BM, Bonney RJ, Dorn C, Finke P, Fletcher D, Hanlon WA, Humes JL, Maycock A, Mumford RA, et al. Davies P, et al. Among authors: humes jl. Ann N Y Acad Sci. 1991;624:219-29. doi: 10.1111/j.1749-6632.1991.tb17021.x. Ann N Y Acad Sci. 1991. PMID: 2064223 Review. No abstract available.

6

The in vitro and in vivo recovery of PMN elastase:beta-lactam inhibitor complexes by cation exchange chromatography.

Opas EE, Dellea PS, Fletcher DS, Davies P, Humes JL. Opas EE, et al. Among authors: humes jl. Ann N Y Acad Sci. 1991;624:348-9. doi: 10.1111/j.1749-6632.1991.tb17044.x. Ann N Y Acad Sci. 1991. PMID: 2064243 No abstract available.

7

Synthesis and release of oxygenation products of arachidonic acid by mononuclear phagocytes in response to inflammatory stimuli.

Davies P, Bonney RJ, Humes JL, Kuehl FA Jr. Davies P, et al. Among authors: humes jl. Inflammation. 1977 Dec;2(4):335-44. doi: 10.1007/BF00921012. Inflammation. 1977. PMID: 617958 No abstract available.

8

The effect of anti-rheumatic agents on macrophage function.

Davies P, Bonney RJ, Humes JL, Kuehl FA Jr. Davies P, et al. Among authors: humes jl. Int J Immunopharmacol. 1982;4(2):111-8. doi: 10.1016/0192-0561(82)90058-3. Int J Immunopharmacol. 1982. PMID: 7047415 Review. No abstract available.

9

Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.

Guthikonda RN, Shah SK, Pacholok SG, Humes JL, Mumford RA, Grant SK, Chabin RM, Green BG, Tsou N, Ball R, Fletcher DS, Luell S, Euan MacIntyre D, Maccoss M. Guthikonda RN, et al. Among authors: humes jl. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. doi: 10.1016/j.bmcl.2005.02.067. Bioorg Med Chem Lett. 2005. PMID: 15808455

10

Macrophages responding to inflammatory stimuli synthesise increased amounts of prostaglandins.

Davies P, Bonney RJ, Humes JL, Kuehl FA Jr. Davies P, et al. Among authors: humes jl. Agents Actions Suppl. 1979;(6):143-9. doi: 10.1007/978-3-0348-7232-4_16. Agents Actions Suppl. 1979. PMID: 294142 No abstract available.

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