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The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K. Marotta LL, et al. J Clin Invest. 2011 Jul;121(7):2723-35. doi: 10.1172/JCI44745. J Clin Invest. 2011. PMID: 21633165 Free PMC article.
Cancer stem cells: a model in the making.
Marotta LL, Polyak K. Marotta LL, et al. Curr Opin Genet Dev. 2009 Feb;19(1):44-50. doi: 10.1016/j.gde.2008.12.003. Epub 2009 Jan 21. Curr Opin Genet Dev. 2009. PMID: 19167210 Review.