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Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study.
Merrill JT, Wallace DJ, Petri M, Kirou KA, Yao Y, White WI, Robbie G, Levin R, Berney SM, Chindalore V, Olsen N, Richman L, Le C, Jallal B, White B; Lupus Interferon Skin Activity (LISA) Study Investigators. Merrill JT, et al. Among authors: jallal b. Ann Rheum Dis. 2011 Nov;70(11):1905-13. doi: 10.1136/ard.2010.144485. Epub 2011 Jul 27. Ann Rheum Dis. 2011. PMID: 21798883 Clinical Trial.
Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway.
Higgs BW, Liu Z, White B, Zhu W, White WI, Morehouse C, Brohawn P, Kiener PA, Richman L, Fiorentino D, Greenberg SA, Jallal B, Yao Y. Higgs BW, et al. Among authors: jallal b. Ann Rheum Dis. 2011 Nov;70(11):2029-36. doi: 10.1136/ard.2011.150326. Epub 2011 Jul 28. Ann Rheum Dis. 2011. PMID: 21803750 Clinical Trial.
A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients.
Higgs BW, Zhu W, Morehouse C, White WI, Brohawn P, Guo X, Rebelatto M, Le C, Amato A, Fiorentino D, Greenberg SA, Drappa J, Richman L, Greth W, Jallal B, Yao Y. Higgs BW, et al. Among authors: jallal b. Ann Rheum Dis. 2014 Jan;73(1):256-62. doi: 10.1136/annrheumdis-2012-202794. Epub 2013 Feb 23. Ann Rheum Dis. 2014. PMID: 23434567 Free PMC article. Clinical Trial.
Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus.
Yao Y, Richman L, Higgs BW, Morehouse CA, de los Reyes M, Brohawn P, Zhang J, White B, Coyle AJ, Kiener PA, Jallal B. Yao Y, et al. Among authors: jallal b. Arthritis Rheum. 2009 Jun;60(6):1785-96. doi: 10.1002/art.24557. Arthritis Rheum. 2009. PMID: 19479852 Free article. Clinical Trial.
Biomarkers for systemic lupus erythematosus.
Herbst R, Liu Z, Jallal B, Yao Y. Herbst R, et al. Among authors: jallal b. Int J Rheum Dis. 2012 Oct;15(5):433-44. doi: 10.1111/j.1756-185X.2012.01764.x. Epub 2012 Jul 9. Int J Rheum Dis. 2012. PMID: 23083033 Review.
Type I interferon: potential therapeutic target for psoriasis?
Yao Y, Richman L, Morehouse C, de los Reyes M, Higgs BW, Boutrin A, White B, Coyle A, Krueger J, Kiener PA, Jallal B. Yao Y, et al. Among authors: jallal b. PLoS One. 2008 Jul 16;3(7):e2737. doi: 10.1371/journal.pone.0002737. PLoS One. 2008. PMID: 18648529 Free PMC article.
Type I interferons in Sjögren's syndrome.
Yao Y, Liu Z, Jallal B, Shen N, Rönnblom L. Yao Y, et al. Among authors: jallal b. Autoimmun Rev. 2013 Mar;12(5):558-66. doi: 10.1016/j.autrev.2012.10.006. Epub 2012 Nov 30. Autoimmun Rev. 2013. PMID: 23201923 Free article. Review.
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