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Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation.
Schneider I, Reverse D, Dewachter I, Ris L, Caluwaerts N, Kuiperi C, Gilis M, Geerts H, Kretzschmar H, Godaux E, Moechars D, Van Leuven F, Herms J. Schneider I, et al. Among authors: van leuven f. J Biol Chem. 2001 Apr 13;276(15):11539-44. doi: 10.1074/jbc.M010977200. Epub 2001 Jan 23. J Biol Chem. 2001. PMID: 11278803 Free article.
Mutant human presenilin-1 (PS1) causes an Alzheimer's-related phenotype in the brain of transgenic mice in combination with mutant human amyloid precursor protein by means of increased production of amyloid peptides (Dewachter, I., Van Dorpe, J., Smeijers, L., Gilis, M., K …
Mutant human presenilin-1 (PS1) causes an Alzheimer's-related phenotype in the brain of transgenic mice in combination with mutant human amy …
Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models.
Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, Van Leuven F, Okamura N, Herms J, Rominger A. Brendel M, et al. Among authors: van leuven f. J Nucl Med. 2016 May;57(5):792-8. doi: 10.2967/jnumed.115.163493. Epub 2016 Feb 11. J Nucl Med. 2016. PMID: 26912432 Free article.
Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice.
Dewachter I, Filipkowski RK, Priller C, Ris L, Neyton J, Croes S, Terwel D, Gysemans M, Devijver H, Borghgraef P, Godaux E, Kaczmarek L, Herms J, Van Leuven F. Dewachter I, et al. Among authors: van leuven f. Neurobiol Aging. 2009 Feb;30(2):241-56. doi: 10.1016/j.neurobiolaging.2007.06.011. Epub 2007 Jul 27. Neurobiol Aging. 2009. PMID: 17673336
341 results