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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Figueroa ME, et al. Among authors: lu c. Cancer Cell. 2010 Dec 14;18(6):553-67. doi: 10.1016/j.ccr.2010.11.015. Epub 2010 Dec 9. Cancer Cell. 2010. PMID: 21130701 Free PMC article.
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.
Cheong H, Lindsten T, Wu J, Lu C, Thompson CB. Cheong H, et al. Among authors: lu c. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11121-6. doi: 10.1073/pnas.1107969108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690395 Free PMC article.
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LG, Huse JT, Mellinghoff IK, Chan TA. Turcan S, et al. Among authors: lu c. Nature. 2012 Feb 15;483(7390):479-83. doi: 10.1038/nature10866. Nature. 2012. PMID: 22343889 Free PMC article.
Metabolic regulation of epigenetics.
Lu C, Thompson CB. Lu C, et al. Cell Metab. 2012 Jul 3;16(1):9-17. doi: 10.1016/j.cmet.2012.06.001. Cell Metab. 2012. PMID: 22768835 Free PMC article.
Therapeutic targets in cancer cell metabolism and autophagy.
Cheong H, Lu C, Lindsten T, Thompson CB. Cheong H, et al. Among authors: lu c. Nat Biotechnol. 2012 Jul 10;30(7):671-8. doi: 10.1038/nbt.2285. Nat Biotechnol. 2012. PMID: 22781696 Free PMC article. Review.
Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas.
Venneti S, Felicella MM, Coyne T, Phillips JJ, Gorovets D, Huse JT, Kofler J, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Perry A, Thompson CB. Venneti S, et al. Among authors: lu c. J Neuropathol Exp Neurol. 2013 Apr;72(4):298-306. doi: 10.1097/NEN.0b013e3182898113. J Neuropathol Exp Neurol. 2013. PMID: 23481705 Free PMC article.
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