Shen R - Search Results

1

Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells.

Koul D, Fu J, Shen R, LaFortune TA, Wang S, Tiao N, Kim YW, Liu JL, Ramnarian D, Yuan Y, Garcia-Echevrria C, Maira SM, Yung WK. Koul D, et al. Among authors: shen r. Clin Cancer Res. 2012 Jan 1;18(1):184-95. doi: 10.1158/1078-0432.CCR-11-1558. Epub 2011 Nov 7. Clin Cancer Res. 2012. PMID: 22065080 Free PMC article.

2

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas.

Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM, Garcia-Echevrria C, Yung WK. Liu TJ, et al. Mol Cancer Ther. 2009 Aug;8(8):2204-10. doi: 10.1158/1535-7163.MCT-09-0160. Epub 2009 Aug 11. Mol Cancer Ther. 2009. PMID: 19671762 Free PMC article.

3

Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.

Koul D, Shen R, Bergh S, Sheng X, Shishodia S, Lafortune TA, Lu Y, de Groot JF, Mills GB, Yung WK. Koul D, et al. Among authors: shen r. Mol Cancer Ther. 2006 Mar;5(3):637-44. doi: 10.1158/1535-7163.MCT-05-0453. Mol Cancer Ther. 2006. PMID: 16546978

4

Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.

Koul D, Shen R, Kim YW, Kondo Y, Lu Y, Bankson J, Ronen SM, Kirkpatrick DL, Powis G, Yung WK. Koul D, et al. Among authors: shen r. Neuro Oncol. 2010 Jun;12(6):559-69. doi: 10.1093/neuonc/nop058. Epub 2010 Feb 15. Neuro Oncol. 2010. PMID: 20156803 Free PMC article.

5

Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy.

Guan S, Shen R, Lafortune T, Tiao N, Houghton P, Yung WK, Koul D. Guan S, et al. Among authors: shen r. Neuro Oncol. 2011 Jul;13(7):748-58. doi: 10.1093/neuonc/nor037. Epub 2011 Jun 8. Neuro Oncol. 2011. PMID: 21653596 Free PMC article.

6

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.

Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB, Yung WK. Koul D, et al. Among authors: shen r. Oncogene. 2002 Apr 4;21(15):2357-64. doi: 10.1038/sj.onc.1205296. Oncogene. 2002. PMID: 11948419

7

MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer.

Koul D, Shen R, Garyali A, Ke LD, Liu TJ, Yung WK. Koul D, et al. Among authors: shen r. Int J Oncol. 2002 Sep;21(3):469-75. Int J Oncol. 2002. PMID: 12168088

8

Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.

Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK. Koul D, et al. Among authors: shen r. Mol Cancer Ther. 2005 Nov;4(11):1681-8. doi: 10.1158/1535-7163.MCT-05-0258. Mol Cancer Ther. 2005. PMID: 16275989

9

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.

Koul D, Takada Y, Shen R, Aggarwal BB, Yung WK. Koul D, et al. Among authors: shen r. Biochem Biophys Res Commun. 2006 Nov 17;350(2):463-71. doi: 10.1016/j.bbrc.2006.09.077. Epub 2006 Sep 25. Biochem Biophys Res Commun. 2006. PMID: 17011514 Free PMC article.

10

PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.

Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK. Koul D, et al. Among authors: shen r. Mol Cell Biochem. 2007 Jun;300(1-2):77-87. doi: 10.1007/s11010-006-9371-8. Epub 2007 Jan 18. Mol Cell Biochem. 2007. PMID: 17235455

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