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Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases.
Oka Y, Yabuuchi T, Oi T, Kuroda S, Fujii Y, Ohtake H, Inoue T, Wakahara S, Kimura K, Fujita K, Endo M, Taguchi K, Sekiguchi Y. Oka Y, et al. Among authors: inoue t. Bioorg Med Chem. 2013 Dec 15;21(24):7578-83. doi: 10.1016/j.bmc.2013.10.042. Epub 2013 Nov 7. Bioorg Med Chem. 2013. PMID: 24262886
Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice.
Arai I, Takaoka A, Hashimoto Y, Honma Y, Koizumi C, Futaki N, Sugimoto M, Takahashi N, Inoue T, Nakanishi Y, Sakurai T, Tanami T, Yagi M, Ono N, Nakaike S. Arai I, et al. Among authors: inoue t. Eur J Pharmacol. 2007 Feb 5;556(1-3):207-14. doi: 10.1016/j.ejphar.2006.10.064. Epub 2006 Nov 3. Eur J Pharmacol. 2007. PMID: 17141215
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