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Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.
Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, Cemerlang N, Sadoshima J, Shioi T, Izumo S, Lukoshkova EV, Dart AM, Jennings GL, McMullen JR. Pretorius L, et al. Among authors: mcmullen jr. Am J Pathol. 2009 Sep;175(3):998-1009. doi: 10.2353/ajpath.2009.090126. Epub 2009 Aug 13. Am J Pathol. 2009. PMID: 19679877 Free PMC article.
PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.
Lin RC, Weeks KL, Gao XM, Williams RB, Bernardo BC, Kiriazis H, Matthews VB, Woodcock EA, Bouwman RD, Mollica JP, Speirs HJ, Dawes IW, Daly RJ, Shioi T, Izumo S, Febbraio MA, Du XJ, McMullen JR. Lin RC, et al. Among authors: mcmullen jr. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):724-32. doi: 10.1161/ATVBAHA.109.201988. Arterioscler Thromb Vasc Biol. 2010. PMID: 20237330
Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.
Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR. Weeks KL, et al. Among authors: mcmullen jr. Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15. Circ Heart Fail. 2012. PMID: 22705768
Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.
Ritchie RH, Love JE, Huynh K, Bernardo BC, Henstridge DC, Kiriazis H, Tham YK, Sapra G, Qin C, Cemerlang N, Boey EJ, Jandeleit-Dahm K, Du XJ, McMullen JR. Ritchie RH, et al. Among authors: mcmullen jr. Diabetologia. 2012 Dec;55(12):3369-81. doi: 10.1007/s00125-012-2720-0. Epub 2012 Sep 22. Diabetologia. 2012. PMID: 23001375
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.
Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR. Bernardo BC, et al. Among authors: mcmullen jr. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9. Proc Natl Acad Sci U S A. 2012. PMID: 23047694 Free PMC article.
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.
Winbanks CE, Chen JL, Qian H, Liu Y, Bernardo BC, Beyer C, Watt KI, Thomson RE, Connor T, Turner BJ, McMullen JR, Larsson L, McGee SL, Harrison CA, Gregorevic P. Winbanks CE, et al. Among authors: mcmullen jr. J Cell Biol. 2013 Oct 28;203(2):345-57. doi: 10.1083/jcb.201211134. Epub 2013 Oct 21. J Cell Biol. 2013. PMID: 24145169 Free PMC article.
168 results