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Page 1
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
McCabe MT, Graves AP, Ganji G, Diaz E, Halsey WS, Jiang Y, Smitheman KN, Ott HM, Pappalardi MB, Allen KE, Chen SB, Della Pietra A 3rd, Dul E, Hughes AM, Gilbert SA, Thrall SH, Tummino PJ, Kruger RG, Brandt M, Schwartz B, Creasy CL. McCabe MT, et al. Among authors: thrall sh. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2989-94. doi: 10.1073/pnas.1116418109. Epub 2012 Feb 8. Proc Natl Acad Sci U S A. 2012. PMID: 22323599 Free PMC article.
Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.
Diaz E, Machutta CA, Chen S, Jiang Y, Nixon C, Hofmann G, Key D, Sweitzer S, Patel M, Wu Z, Creasy CL, Kruger RG, LaFrance L, Verma SK, Pappalardi MB, Le B, Van Aller GS, McCabe MT, Tummino PJ, Pope AJ, Thrall SH, Schwartz B, Brandt M. Diaz E, et al. Among authors: thrall sh. J Biomol Screen. 2012 Dec;17(10):1279-92. doi: 10.1177/1087057112453765. Epub 2012 Aug 17. J Biomol Screen. 2012. PMID: 22904200
Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36.
Poulin MB, Schneck JL, Matico RE, McDevitt PJ, Huddleston MJ, Hou W, Johnson NW, Thrall SH, Meek TD, Schramm VL. Poulin MB, et al. Among authors: thrall sh. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1197-201. doi: 10.1073/pnas.1521036113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787850 Free PMC article.
A simple assay for detection of small-molecule redox activity.
Lor LA, Schneck J, McNulty DE, Diaz E, Brandt M, Thrall SH, Schwartz B. Lor LA, et al. Among authors: thrall sh. J Biomol Screen. 2007 Sep;12(6):881-90. doi: 10.1177/1087057107304113. Epub 2007 Jun 19. J Biomol Screen. 2007. PMID: 17579124
A high-throughput screen for endothelial lipase using HDL as substrate.
Keller PM, Rust T, Murphy DJ, Matico R, Trill JJ, Krawiec JA, Jurewicz A, Jaye M, Harpel M, Thrall S, Schwartz B. Keller PM, et al. J Biomol Screen. 2008 Jul;13(6):468-75. doi: 10.1177/1087057108319738. Epub 2008 Jun 19. J Biomol Screen. 2008. PMID: 18566479
A high-throughput screen measuring ubiquitination of p53 by human mdm2.
Murray MF, Jurewicz AJ, Martin JD, Ho TF, Zhang H, Johanson KO, Kirkpatrick RB, Ma J, Lor LA, Thrall SH, Schwartz B. Murray MF, et al. Among authors: thrall sh. J Biomol Screen. 2007 Dec;12(8):1050-8. doi: 10.1177/1087057107308556. Epub 2007 Nov 7. J Biomol Screen. 2007. PMID: 17989425
25 results