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IAPs limit activation of RIP kinases by TNF receptor 1 during development.
Moulin M, Anderton H, Voss AK, Thomas T, Wong WW, Bankovacki A, Feltham R, Chau D, Cook WD, Silke J, Vaux DL. Moulin M, et al. Among authors: cook wd. EMBO J. 2012 Apr 4;31(7):1679-91. doi: 10.1038/emboj.2012.18. Epub 2012 Feb 10. EMBO J. 2012. PMID: 22327219 Free PMC article.
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: cook wd. J Biol Chem. 2011 Apr 15;286(15):13282-91. doi: 10.1074/jbc.M110.216226. Epub 2011 Feb 21. J Biol Chem. 2011. PMID: 21339290 Free PMC article.
Response to Heard et al.
Moulin M, Voss AK, Thomas T, Wong WW, Cook WD, Koentgen F, Vince J, Silke J, Vaux DL. Moulin M, et al. Among authors: cook wd. EMBO J. 2015 Oct 1;34(19):2396-7. doi: 10.15252/embj.201592761. EMBO J. 2015. PMID: 26427759 Free PMC article. No abstract available.
In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.
Moujalled DM, Cook WD, Lluis JM, Khan NR, Ahmed AU, Callus BA, Vaux DL. Moujalled DM, et al. Among authors: cook wd. Cell Death Differ. 2012 May;19(5):808-15. doi: 10.1038/cdd.2011.151. Epub 2011 Nov 18. Cell Death Differ. 2012. PMID: 22095280 Free PMC article.
Necroptosis induced by RIPK3 requires MLKL but not Drp1.
Moujalled DM, Cook WD, Murphy JM, Vaux DL. Moujalled DM, et al. Among authors: cook wd. Cell Death Dis. 2014 Feb 27;5(2):e1086. doi: 10.1038/cddis.2014.18. Cell Death Dis. 2014. PMID: 24577084 Free PMC article.
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: cook wd. J Biol Chem. 2016 Jan 29;291(5):2547. doi: 10.1074/jbc.A110.216226. J Biol Chem. 2016. PMID: 26826208 Free PMC article. No abstract available.
81 results