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Page 1
IAPs limit activation of RIP kinases by TNF receptor 1 during development.
Moulin M, Anderton H, Voss AK, Thomas T, Wong WW, Bankovacki A, Feltham R, Chau D, Cook WD, Silke J, Vaux DL. Moulin M, et al. Among authors: vaux dl. EMBO J. 2012 Apr 4;31(7):1679-91. doi: 10.1038/emboj.2012.18. Epub 2012 Feb 10. EMBO J. 2012. PMID: 22327219 Free PMC article.
IAPs, RINGs and ubiquitylation.
Vaux DL, Silke J. Vaux DL, et al. Nat Rev Mol Cell Biol. 2005 Apr;6(4):287-97. doi: 10.1038/nrm1621. Nat Rev Mol Cell Biol. 2005. PMID: 15803136 Review.
Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.
Feltham R, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J. Feltham R, et al. Among authors: vaux dl. J Biol Chem. 2010 Jun 4;285(23):17525-36. doi: 10.1074/jbc.M109.087635. Epub 2010 Mar 30. J Biol Chem. 2010. PMID: 20356846 Free PMC article.
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: vaux dl. J Biol Chem. 2011 Apr 15;286(15):13282-91. doi: 10.1074/jbc.M110.216226. Epub 2011 Feb 21. J Biol Chem. 2011. PMID: 21339290 Free PMC article.
Response to Heard et al.
Moulin M, Voss AK, Thomas T, Wong WW, Cook WD, Koentgen F, Vince J, Silke J, Vaux DL. Moulin M, et al. Among authors: vaux dl. EMBO J. 2015 Oct 1;34(19):2396-7. doi: 10.15252/embj.201592761. EMBO J. 2015. PMID: 26427759 Free PMC article. No abstract available.
RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.
Wong WW, Gentle IE, Nachbur U, Anderton H, Vaux DL, Silke J. Wong WW, et al. Among authors: vaux dl. Cell Death Differ. 2010 Mar;17(3):482-7. doi: 10.1038/cdd.2009.178. Epub 2009 Nov 20. Cell Death Differ. 2010. PMID: 19927158
Mammalian mitochondrial IAP binding proteins.
Vaux DL, Silke J. Vaux DL, et al. Biochem Biophys Res Commun. 2003 May 9;304(3):499-504. doi: 10.1016/s0006-291x(03)00622-3. Biochem Biophys Res Commun. 2003. PMID: 12729584 Review.
HtrA2/Omi, a sheep in wolf's clothing.
Vaux DL, Silke J. Vaux DL, et al. Cell. 2003 Oct 31;115(3):251-3. doi: 10.1016/s0092-8674(03)00851-1. Cell. 2003. PMID: 14636553 Free article.
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J. Vince JE, et al. Among authors: vaux dl. Cell. 2007 Nov 16;131(4):682-93. doi: 10.1016/j.cell.2007.10.037. Cell. 2007. PMID: 18022363 Free article.
177 results