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DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists.
Naqvi I, Giroux N, Olson L, Morrison SA, Llanga T, Akinade TO, Zhu Y, Zhong Y, Bose S, Arvai S, Abramson K, Chen L, Que L, Kraft B, Shen X, Lee J, Leong KW, Nair SK, Sullenger B. Naqvi I, et al. Among authors: arvai s. Biomaterials. 2022 Apr;283:121393. doi: 10.1016/j.biomaterials.2022.121393. Epub 2022 Jan 28. Biomaterials. 2022. PMID: 35349874 Free PMC article.