Ward SA - Search Results

1

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

Leung SC, Gibbons P, Amewu R, Nixon GL, Pidathala C, Hong WD, Pacorel B, Berry NG, Sharma R, Stocks PA, Srivastava A, Shone AE, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Hill A, Fisher NE, Warman AJ, Biagini GA, Ward SA, O'Neill PM. Leung SC, et al. Among authors: ward sa. J Med Chem. 2012 Mar 8;55(5):1844-57. doi: 10.1021/jm201184h. Epub 2012 Feb 24. J Med Chem. 2012. PMID: 22364417 Free PMC article.

2

The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.

Ruscoe JE, Jewell H, Maggs JL, O'Neill PM, Storr RC, Ward SA, Park BK. Ruscoe JE, et al. Among authors: ward sa. J Pharmacol Exp Ther. 1995 Apr;273(1):393-404. J Pharmacol Exp Ther. 1995. PMID: 7714794

3

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

O'Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK. O'Neill PM, et al. Among authors: ward sa. J Med Chem. 1994 Apr 29;37(9):1362-70. doi: 10.1021/jm00035a017. J Med Chem. 1994. PMID: 8176713

4

Malaria chemotherapy: resistance to quinoline containing drugs in Plasmodium falciparum.

Bray PG, Ward SA. Bray PG, et al. Among authors: ward sa. FEMS Microbiol Lett. 1993 Oct 1;113(1):1-7. doi: 10.1111/j.1574-6968.1993.tb06479.x. FEMS Microbiol Lett. 1993. PMID: 8243975 Review.

5

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

Hawley SR, Bray PG, O'Neill PM, Park BK, Ward SA. Hawley SR, et al. Among authors: ward sa. Biochem Pharmacol. 1996 Sep 13;52(5):723-33. doi: 10.1016/0006-2952(96)00354-1. Biochem Pharmacol. 1996. PMID: 8765470

6

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.

Hawley SR, Bray PG, O'Neill PM, Naisbitt DJ, Park BK, Ward SA. Hawley SR, et al. Among authors: ward sa. Antimicrob Agents Chemother. 1996 Oct;40(10):2345-9. doi: 10.1128/AAC.40.10.2345. Antimicrob Agents Chemother. 1996. PMID: 8891142 Free PMC article.

7

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.

O'Neill PM, Bishop LP, Storr RC, Hawley SR, Maggs JL, Ward SA, Park BK. O'Neill PM, et al. Among authors: ward sa. J Med Chem. 1996 Oct 25;39(22):4511-4. doi: 10.1021/jm9604944. J Med Chem. 1996. PMID: 8893847

8

Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum.

Bray PG, Hawley SR, Mungthin M, Ward SA. Bray PG, et al. Among authors: ward sa. Mol Pharmacol. 1996 Dec;50(6):1559-66. Mol Pharmacol. 1996. PMID: 8967978

9

Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.

O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK. O'Neill PM, et al. Among authors: ward sa. J Med Chem. 1997 Feb 14;40(4):437-48. doi: 10.1021/jm960370r. J Med Chem. 1997. PMID: 9046333

10

Quinoline resistance mechanisms in Plasmodium falciparum: the debate goes on.

Ward SA, Bray PG, Hawley SR. Ward SA, et al. Parasitology. 1997;114 Suppl:S125-36. Parasitology. 1997. PMID: 9309774 Review.

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