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Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.
Windahl SH, Saxon L, Börjesson AE, Lagerquist MK, Frenkel B, Henning P, Lerner UH, Galea GL, Meakin LB, Engdahl C, Sjögren K, Antal MC, Krust A, Chambon P, Lanyon LE, Price JS, Ohlsson C. Windahl SH, et al. Among authors: meakin lb. J Bone Miner Res. 2013 Feb;28(2):291-301. doi: 10.1002/jbmr.1754. J Bone Miner Res. 2013. PMID: 22972752 Free PMC article.
Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.
Galea GL, Meakin LB, Sugiyama T, Zebda N, Sunters A, Taipaleenmaki H, Stein GS, van Wijnen AJ, Lanyon LE, Price JS. Galea GL, et al. Among authors: meakin lb. J Biol Chem. 2013 Mar 29;288(13):9035-48. doi: 10.1074/jbc.M112.405456. Epub 2013 Jan 29. J Biol Chem. 2013. PMID: 23362266 Free PMC article.
43 results