Radhakrishnan R - Search Results

1

Structural systems biology and multiscale signaling models.

Telesco SE, Radhakrishnan R. Telesco SE, et al. Among authors: radhakrishnan r. Ann Biomed Eng. 2012 Nov;40(11):2295-306. doi: 10.1007/s10439-012-0576-6. Epub 2012 Apr 27. Ann Biomed Eng. 2012. PMID: 22539148 Free PMC article. Review.

2

A multiscale computational approach to dissect early events in the Erb family receptor mediated activation, differential signaling, and relevance to oncogenic transformations.

Liu Y, Purvis J, Shih A, Weinstein J, Agrawal N, Radhakrishnan R. Liu Y, et al. Among authors: radhakrishnan r. Ann Biomed Eng. 2007 Jun;35(6):1012-25. doi: 10.1007/s10439-006-9251-0. Epub 2007 Feb 2. Ann Biomed Eng. 2007. PMID: 17273938 Free PMC article.

3

Steady-state kinetic modeling constrains cellular resting states and dynamic behavior.

Purvis JE, Radhakrishnan R, Diamond SL. Purvis JE, et al. Among authors: radhakrishnan r. PLoS Comput Biol. 2009 Mar;5(3):e1000298. doi: 10.1371/journal.pcbi.1000298. Epub 2009 Mar 6. PLoS Comput Biol. 2009. PMID: 19266013 Free PMC article.

4

Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study.

Telesco SE, Radhakrishnan R. Telesco SE, et al. Among authors: radhakrishnan r. Biophys J. 2009 Mar 18;96(6):2321-34. doi: 10.1016/j.bpj.2008.12.3912. Biophys J. 2009. PMID: 19289058 Free PMC article.

5

Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing.

Shih AJ, Purvis J, Radhakrishnan R. Shih AJ, et al. Among authors: radhakrishnan r. Mol Biosyst. 2008 Dec;4(12):1151-9. doi: 10.1039/b803806f. Epub 2008 Sep 12. Mol Biosyst. 2008. PMID: 19396377 Free PMC article.

6

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.

Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA. Shi F, et al. Among authors: radhakrishnan r. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7692-7. doi: 10.1073/pnas.1002753107. Epub 2010 Mar 29. Proc Natl Acad Sci U S A. 2010. PMID: 20351256 Free PMC article.

7

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases.

Shih AJ, Telesco SE, Choi SH, Lemmon MA, Radhakrishnan R. Shih AJ, et al. Among authors: radhakrishnan r. Biochem J. 2011 Jun 1;436(2):241-51. doi: 10.1042/BJ20101791. Biochem J. 2011. PMID: 21426301 Free PMC article.

8

A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network.

Telesco SE, Shih AJ, Jia F, Radhakrishnan R. Telesco SE, et al. Among authors: radhakrishnan r. Mol Biosyst. 2011 Jun;7(6):2066-80. doi: 10.1039/c0mb00345j. Epub 2011 Apr 20. Mol Biosyst. 2011. PMID: 21509365 Free PMC article.

9

Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases.

Shih AJ, Telesco SE, Radhakrishnan R. Shih AJ, et al. Among authors: radhakrishnan r. Cancers (Basel). 2011 Mar;3(1):1195-231. doi: 10.3390/cancers3011195. Cancers (Basel). 2011. PMID: 21701703 Free PMC article.

10

Systems biology and physical biology of clathrin-mediated endocytosis.

Ramanan V, Agrawal NJ, Liu J, Engles S, Toy R, Radhakrishnan R. Ramanan V, et al. Among authors: radhakrishnan r. Integr Biol (Camb). 2011 Aug;3(8):803-15. doi: 10.1039/c1ib00036e. Epub 2011 Jul 26. Integr Biol (Camb). 2011. PMID: 21792431 Free PMC article. Review.

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