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Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Lee J, Komatsu K, Lee BC, Lim JH, Jono H, Xu H, Kai H, Zhang ZJ, Yan C, Li JD. Lee J, et al. Among authors: xu h. J Biol Chem. 2012 Jun 29;287(27):22799-811. doi: 10.1074/jbc.M111.337378. Epub 2012 May 18. J Biol Chem. 2012. PMID: 22610099 Free PMC article.
Transforming growth factor-beta-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK.
Jono H, Xu H, Kai H, Lim DJ, Kim YS, Feng XH, Li JD. Jono H, et al. Among authors: xu h. J Biol Chem. 2003 Jul 25;278(30):27811-9. doi: 10.1074/jbc.M301773200. Epub 2003 May 6. J Biol Chem. 2003. PMID: 12734193 Free article.
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt.
Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD. Lim JH, et al. Among authors: xu x, xu h. Nat Commun. 2012 Apr 10;3:771. doi: 10.1038/ncomms1776. Nat Commun. 2012. PMID: 22491319 Free PMC article.
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase.
Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, Rixter DD, Kai H, Andalibi A, Linthicum F, Guan YL, Han J, Cato AC, Lim DJ, Akira S, Li JD. Shuto T, et al. Among authors: xu h. J Biol Chem. 2002 May 10;277(19):17263-70. doi: 10.1074/jbc.M112190200. Epub 2002 Feb 26. J Biol Chem. 2002. PMID: 11867630 Free article.
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