Mootha VK - Search Results

1

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.

Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Jain M, et al. Among authors: mootha vk. Science. 2012 May 25;336(6084):1040-4. doi: 10.1126/science.1218595. Science. 2012. PMID: 22628656 Free PMC article.

2

Systematic identification of human mitochondrial disease genes through integrative genomics.

Calvo S, Jain M, Xie X, Sheth SA, Chang B, Goldberger OA, Spinazzola A, Zeviani M, Carr SA, Mootha VK. Calvo S, et al. Among authors: mootha vk. Nat Genet. 2006 May;38(5):576-82. doi: 10.1038/ng1776. Epub 2006 Apr 2. Nat Genet. 2006. PMID: 16582907

3

Large-scale chemical dissection of mitochondrial function.

Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK. Wagner BK, et al. Among authors: mootha vk. Nat Biotechnol. 2008 Mar;26(3):343-51. doi: 10.1038/nbt1387. Epub 2008 Feb 24. Nat Biotechnol. 2008. PMID: 18297058 Free PMC article.

4

Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, Kingsley PD, Culotta VC, Kaplan J, Palis J, Paw BH, Mootha VK. Nilsson R, et al. Among authors: mootha vk. Cell Metab. 2009 Aug;10(2):119-30. doi: 10.1016/j.cmet.2009.06.012. Cell Metab. 2009. PMID: 19656490 Free PMC article.

5

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis.

Baughman JM, Nilsson R, Gohil VM, Arlow DH, Gauhar Z, Mootha VK. Baughman JM, et al. Among authors: mootha vk. PLoS Genet. 2009 Aug;5(8):e1000590. doi: 10.1371/journal.pgen.1000590. Epub 2009 Aug 14. PLoS Genet. 2009. PMID: 19680543 Free PMC article.

6

A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells.

Shaham O, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, Clish CB, Sims KB, Mootha VK. Shaham O, et al. Among authors: mootha vk. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1571-5. doi: 10.1073/pnas.0906039107. Epub 2010 Jan 8. Proc Natl Acad Sci U S A. 2010. PMID: 20080599 Free PMC article.

7

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.

Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK. Gohil VM, et al. Among authors: mootha vk. Nat Biotechnol. 2010 Mar;28(3):249-55. doi: 10.1038/nbt.1606. Epub 2010 Feb 14. Nat Biotechnol. 2010. PMID: 20160716 Free PMC article.

8

Mitochondrial and nuclear genomic responses to loss of LRPPRC expression.

Gohil VM, Nilsson R, Belcher-Timme CA, Luo B, Root DE, Mootha VK. Gohil VM, et al. Among authors: mootha vk. J Biol Chem. 2010 Apr 30;285(18):13742-7. doi: 10.1074/jbc.M109.098400. Epub 2010 Mar 10. J Biol Chem. 2010. PMID: 20220140 Free PMC article.

9

Metabolite profiles and the risk of developing diabetes.

Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE. Wang TJ, et al. Among authors: mootha vk. Nat Med. 2011 Apr;17(4):448-53. doi: 10.1038/nm.2307. Epub 2011 Mar 20. Nat Med. 2011. PMID: 21423183 Free PMC article.

10

Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.

Leoni V, Strittmatter L, Zorzi G, Zibordi F, Dusi S, Garavaglia B, Venco P, Caccia C, Souza AL, Deik A, Clish CB, Rimoldi M, Ciusani E, Bertini E, Nardocci N, Mootha VK, Tiranti V. Leoni V, et al. Among authors: mootha vk. Mol Genet Metab. 2012 Mar;105(3):463-71. doi: 10.1016/j.ymgme.2011.12.005. Epub 2011 Dec 14. Mol Genet Metab. 2012. PMID: 22221393 Free PMC article.

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