Zvyaga T - Search Results

1

Evaluation of six proton pump inhibitors as inhibitors of various human cytochromes P450: focus on cytochrome P450 2C19.

Zvyaga T, Chang SY, Chen C, Yang Z, Vuppugalla R, Hurley J, Thorndike D, Wagner A, Chimalakonda A, Rodrigues AD. Zvyaga T, et al. Drug Metab Dispos. 2012 Sep;40(9):1698-711. doi: 10.1124/dmd.112.045575. Epub 2012 May 30. Drug Metab Dispos. 2012. PMID: 22648560

2

Studies to further investigate the inhibition of human liver microsomal CYP2C8 by the acyl-β-glucuronide of gemfibrozil.

Jenkins SM, Zvyaga T, Johnson SR, Hurley J, Wagner A, Burrell R, Turley W, Leet JE, Philip T, Rodrigues AD. Jenkins SM, et al. Among authors: zvyaga t. Drug Metab Dispos. 2011 Dec;39(12):2421-30. doi: 10.1124/dmd.111.041947. Epub 2011 Sep 12. Drug Metab Dispos. 2011. PMID: 21911547

3

Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.

Rodrigues AD, Lai Y, Cvijic ME, Elkin LL, Zvyaga T, Soars MG. Rodrigues AD, et al. Among authors: zvyaga t. Drug Metab Dispos. 2014 Apr;42(4):566-74. doi: 10.1124/dmd.113.054205. Epub 2013 Oct 10. Drug Metab Dispos. 2014. PMID: 24115749 Review.

4

Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.

Haarhoff ZE, Kramer MA, Zvyaga TA, Zhang J, Bhutani P, Subramanian M, Rodrigues AD. Haarhoff ZE, et al. Xenobiotica. 2017 Jun;47(6):470-478. doi: 10.1080/00498254.2016.1203042. Epub 2016 Aug 8. Xenobiotica. 2017. PMID: 27498589

5

Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening.

Haarhoff Z, Wagner A, Picard P, Drexler DM, Zvyaga T, Shou W. Haarhoff Z, et al. Among authors: zvyaga t. J Biomol Screen. 2016 Feb;21(2):165-75. doi: 10.1177/1087057115607184. Epub 2015 Sep 29. J Biomol Screen. 2016. PMID: 26420787

6

Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen.

Wagner AD, Kolb JM, Ozbal CC, Herbst JJ, Olah TV, Weller HN, Zvyaga TA, Shou WZ. Wagner AD, et al. Rapid Commun Mass Spectrom. 2011 May 15;25(9):1231-40. doi: 10.1002/rcm.4984. Rapid Commun Mass Spectrom. 2011. PMID: 21488121

7

Pharmacodynamics-based approach for efficacious human dose projection of BMS-986260, a small molecule transforming growth factor beta receptor 1 inhibitor.

Parrish KE, Swanson J, Cheng L, Luk E, Stetsko P, Smalley J, Shu YZ, Huang J, Pabalan JG, Sun Y, Zvyaga T, Cvijic ME, Burke J, Borzilleri R, Murtaza A, Augustine K, Yang Z. Parrish KE, et al. Among authors: zvyaga t. Biopharm Drug Dispos. 2021 Apr;42(4):137-149. doi: 10.1002/bdd.2256. Epub 2021 Jan 8. Biopharm Drug Dispos. 2021. PMID: 33354831

8

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).

Wu SC, Yoon D, Chin J, van Kirk K, Seethala R, Golla R, He B, Harrity T, Kunselman LK, Morgan NN, Ponticiello RP, Taylor JR, Zebo R, Harper TW, Li W, Wang M, Zhang L, Sleczka BG, Nayeem A, Sheriff S, Camac DM, Morin PE, Everlof JG, Li YX, Ferraro CA, Kieltyka K, Shou W, Vath MB, Zvyaga TA, Gordon DA, Robl JA. Wu SC, et al. Among authors: zvyaga ta. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6693-8. doi: 10.1016/j.bmcl.2011.09.058. Epub 2011 Sep 21. Bioorg Med Chem Lett. 2011. PMID: 21983444

9

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

Wang H, Robl JA, Hamann LG, Simpkins L, Golla R, Li YX, Seethala R, Zvyaga T, Gordon DA, Li JJ. Wang H, et al. Among authors: zvyaga t. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4146-9. doi: 10.1016/j.bmcl.2011.05.101. Bioorg Med Chem Lett. 2011. PMID: 21689935

10

A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen.

Kieltyka K, Zhang J, Li S, Vath M, Baglieri C, Ferraro C, Zvyaga TA, Drexler DM, Weller HN, Shou WZ. Kieltyka K, et al. Rapid Commun Mass Spectrom. 2009 Jun;23(11):1579-91. doi: 10.1002/rcm.4037. Rapid Commun Mass Spectrom. 2009. PMID: 19399765

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