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Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Xiao S, et al. J Exp Med. 2007 Jul 9;204(7):1691-702. doi: 10.1084/jem.20062498. Epub 2007 Jul 2. J Exp Med. 2007. PMID: 17606630 Free PMC article.
Tim-2 regulates T helper type 2 responses and autoimmunity.
Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK. Chakravarti S, et al. Among authors: strom tb. J Exp Med. 2005 Aug 1;202(3):437-44. doi: 10.1084/jem.20050308. Epub 2005 Jul 25. J Exp Med. 2005. PMID: 16043519 Free PMC article.
TIM-4 expressed on APCs induces T cell expansion and survival.
Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. Rodriguez-Manzanet R, et al. Among authors: strom tb. J Immunol. 2008 Apr 1;180(7):4706-13. doi: 10.4049/jimmunol.180.7.4706. J Immunol. 2008. PMID: 18354194 Free PMC article.
522 results