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Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.
Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR. Weeks KL, et al. Among authors: woodcock ea. Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15. Circ Heart Fail. 2012. PMID: 22705768
Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.
Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, Cemerlang N, Sadoshima J, Shioi T, Izumo S, Lukoshkova EV, Dart AM, Jennings GL, McMullen JR. Pretorius L, et al. Among authors: woodcock ea. Am J Pathol. 2009 Sep;175(3):998-1009. doi: 10.2353/ajpath.2009.090126. Epub 2009 Aug 13. Am J Pathol. 2009. PMID: 19679877 Free PMC article.
PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.
Lin RC, Weeks KL, Gao XM, Williams RB, Bernardo BC, Kiriazis H, Matthews VB, Woodcock EA, Bouwman RD, Mollica JP, Speirs HJ, Dawes IW, Daly RJ, Shioi T, Izumo S, Febbraio MA, Du XJ, McMullen JR. Lin RC, et al. Among authors: woodcock ea. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):724-32. doi: 10.1161/ATVBAHA.109.201988. Arterioscler Thromb Vasc Biol. 2010. PMID: 20237330
The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA, McMullen JR. Sapra G, et al. Among authors: woodcock ea. Nat Commun. 2014 Dec 9;5:5705. doi: 10.1038/ncomms6705. Nat Commun. 2014. PMID: 25489988 Free article.
FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu A, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. Weeks KL, et al. Among authors: woodcock ea. Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1470-H1485. doi: 10.1152/ajpheart.00838.2020. Epub 2021 Feb 12. Am J Physiol Heart Circ Physiol. 2021. PMID: 33577435 Free article.
Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.
McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL. McMullen JR, et al. Among authors: woodcock ea. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):612-7. doi: 10.1073/pnas.0606663104. Epub 2007 Jan 3. Proc Natl Acad Sci U S A. 2007. PMID: 17202264 Free PMC article.
197 results