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Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.
Field JJ, Pera B, Calvo E, Canales A, Zurwerra D, Trigili C, Rodríguez-Salarichs J, Matesanz R, Kanakkanthara A, Wakefield SJ, Singh AJ, Jiménez-Barbero J, Northcote P, Miller JH, López JA, Hamel E, Barasoain I, Altmann KH, Díaz JF. Field JJ, et al. Among authors: altmann kh. Chem Biol. 2012 Jun 22;19(6):686-98. doi: 10.1016/j.chembiol.2012.05.008. Chem Biol. 2012. PMID: 22726683 Free PMC article.
The binding mode of side chain- and C3-modified epothilones to tubulin.
Erdélyi M, Navarro-Vázquez A, Pfeiffer B, Kuzniewski CN, Felser A, Widmer T, Gertsch J, Pera B, Díaz JF, Altmann KH, Carlomagno T. Erdélyi M, et al. Among authors: altmann kh. ChemMedChem. 2010 Jun 7;5(6):911-20. doi: 10.1002/cmdc.201000050. ChemMedChem. 2010. PMID: 20432490
Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches.
Canales A, Nieto L, Rodríguez-Salarichs J, Sánchez-Murcia PA, Coderch C, Cortés-Cabrera A, Paterson I, Carlomagno T, Gago F, Andreu JM, Altmann KH, Jiménez-Barbero J, Díaz JF. Canales A, et al. Among authors: altmann kh. ACS Chem Biol. 2014 Apr 18;9(4):1033-43. doi: 10.1021/cb400673h. Epub 2014 Feb 25. ACS Chem Biol. 2014. PMID: 24524625 Free article.
176 results