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Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.
Field JJ, Pera B, Calvo E, Canales A, Zurwerra D, Trigili C, Rodríguez-Salarichs J, Matesanz R, Kanakkanthara A, Wakefield SJ, Singh AJ, Jiménez-Barbero J, Northcote P, Miller JH, López JA, Hamel E, Barasoain I, Altmann KH, Díaz JF. Field JJ, et al. Among authors: canales a. Chem Biol. 2012 Jun 22;19(6):686-98. doi: 10.1016/j.chembiol.2012.05.008. Chem Biol. 2012. PMID: 22726683 Free PMC article.
N'-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile.
Garcia-Rubia A, Lasala F, Ginex T, Morales-Tenorio M, Olal C, Heung M, Oquist P, Galindo I, Cuesta-Geijo MÁ, Casasnovas JM, Campillo NE, Canales Á, Alonso C, Martínez A, Muñoz-Fontela C, Delgado R, Gil C. Garcia-Rubia A, et al. Among authors: canales a. J Med Chem. 2023 Apr 27;66(8):5465-5483. doi: 10.1021/acs.jmedchem.2c01785. Epub 2023 Apr 6. J Med Chem. 2023. PMID: 37021830 Free PMC article.
Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.
Canales A, Rodríguez-Salarichs J, Trigili C, Nieto L, Coderch C, Andreu JM, Paterson I, Jiménez-Barbero J, Díaz JF. Canales A, et al. ACS Chem Biol. 2011 Aug 19;6(8):789-99. doi: 10.1021/cb200099u. Epub 2011 May 13. ACS Chem Biol. 2011. PMID: 21539341 Free article.
128 results