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Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.
Field JJ, Pera B, Calvo E, Canales A, Zurwerra D, Trigili C, Rodríguez-Salarichs J, Matesanz R, Kanakkanthara A, Wakefield SJ, Singh AJ, Jiménez-Barbero J, Northcote P, Miller JH, López JA, Hamel E, Barasoain I, Altmann KH, Díaz JF. Field JJ, et al. Among authors: pera b. Chem Biol. 2012 Jun 22;19(6):686-98. doi: 10.1016/j.chembiol.2012.05.008. Chem Biol. 2012. PMID: 22726683 Free PMC article.
The binding mode of side chain- and C3-modified epothilones to tubulin.
Erdélyi M, Navarro-Vázquez A, Pfeiffer B, Kuzniewski CN, Felser A, Widmer T, Gertsch J, Pera B, Díaz JF, Altmann KH, Carlomagno T. Erdélyi M, et al. Among authors: pera b. ChemMedChem. 2010 Jun 7;5(6):911-20. doi: 10.1002/cmdc.201000050. ChemMedChem. 2010. PMID: 20432490
Mechanism of action of the cytotoxic macrolides amphidinolide X and J.
Trigili C, Pera B, Barbazanges M, Cossy J, Meyer C, Pineda O, Rodríguez-Escrich C, Urpí F, Vilarrasa J, Díaz JF, Barasoain I. Trigili C, et al. Among authors: pera b. Chembiochem. 2011 May 2;12(7):1027-30. doi: 10.1002/cbic.201100042. Epub 2011 Apr 15. Chembiochem. 2011. PMID: 21500335 No abstract available.
Modulation of microtubule interprotofilament interactions by modified taxanes.
Matesanz R, Rodríguez-Salarichs J, Pera B, Canales A, Andreu JM, Jiménez-Barbero J, Bras W, Nogales A, Fang WS, Díaz JF. Matesanz R, et al. Among authors: pera b. Biophys J. 2011 Dec 21;101(12):2970-80. doi: 10.1016/j.bpj.2011.11.005. Epub 2011 Dec 20. Biophys J. 2011. PMID: 22208196 Free PMC article.
Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents.
Milelli A, Tumiatti V, Micco M, Rosini M, Zuccari G, Raffaghello L, Bianchi G, Pistoia V, Fernando Díaz J, Pera B, Trigili C, Barasoain I, Musetti C, Toniolo M, Sissi C, Alcaro S, Moraca F, Zini M, Stefanelli C, Minarini A. Milelli A, et al. Among authors: pera b. Eur J Med Chem. 2012 Nov;57:417-28. doi: 10.1016/j.ejmech.2012.06.045. Epub 2012 Jul 4. Eur J Med Chem. 2012. PMID: 22819507
A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.
Coderch C, Tang Y, Klett J, Zhang SE, Ma YT, Shaorong W, Matesanz R, Pera B, Canales A, Jiménez-Barbero J, Morreale A, Díaz JF, Fang WS, Gago F. Coderch C, et al. Among authors: pera b. Org Biomol Chem. 2013 May 14;11(18):3046-56. doi: 10.1039/c3ob40407b. Org Biomol Chem. 2013. PMID: 23532250 Free article.
New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.
Pera B, Barasoain I, Pantazopoulou A, Canales A, Matesanz R, Rodriguez-Salarichs J, García-Fernandez LF, Moneo V, Jiménez-Barbero J, Galmarini CM, Cuevas C, Peñalva MA, Díaz JF, Andreu JM. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. doi: 10.1021/cb400461j. Epub 2013 Aug 1. ACS Chem Biol. 2013. PMID: 23859655
PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.
Martínez-Díez M, Guillén-Navarro MJ, Pera B, Bouchet BP, Martínez-Leal JF, Barasoain I, Cuevas C, Andreu JM, García-Fernández LF, Díaz JF, Avilés P, Galmarini CM. Martínez-Díez M, et al. Among authors: pera b. Biochem Pharmacol. 2014 Apr 1;88(3):291-302. doi: 10.1016/j.bcp.2014.01.026. Epub 2014 Jan 31. Biochem Pharmacol. 2014. PMID: 24486569
23 results