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In search of authentic inhibitors of HIV-1 integration.
Debyser Z, Cherepanov P, Van Maele B, De Clercq E, Witvrouw M. Debyser Z, et al. Antivir Chem Chemother. 2002 Jan;13(1):1-15. doi: 10.1177/095632020201300101. Antivir Chem Chemother. 2002. PMID: 12180645 Free article. Review.
Novel inhibitors of HIV-1 integration.
Witvrouw M, Van Maele B, Vercammen J, Hantson A, Engelborghs Y, De Clercq E, Pannecouque C, Debyser Z. Witvrouw M, et al. Among authors: debyser z. Curr Drug Metab. 2004 Aug;5(4):291-304. doi: 10.2174/1389200043335487. Curr Drug Metab. 2004. PMID: 15320701 Review.
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.
Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z. Busschots K, et al. Among authors: debyser z. J Biol Chem. 2005 May 6;280(18):17841-7. doi: 10.1074/jbc.M411681200. Epub 2005 Mar 4. J Biol Chem. 2005. PMID: 15749713 Free article.
We have previously shown that the p75 isoform of the transcriptional co-activator lens epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency virus (HIV)-1 integrase (IN) and is essential for nuclear targeting of this protein in human cells (Cherep …
We have previously shown that the p75 isoform of the transcriptional co-activator lens epithelium-derived growth factor (LEDGF) interacts ti …
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.
Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempé D, Vandekerckhove L, Moisant F, Ben-Slama L, Witvrouw M, Christ F, Rain JC, Dargemont C, Debyser Z, Benarous R. Emiliani S, et al. Among authors: debyser z. J Biol Chem. 2005 Jul 8;280(27):25517-23. doi: 10.1074/jbc.M501378200. Epub 2005 Apr 25. J Biol Chem. 2005. PMID: 15855167 Free article.
324 results