Backos DS - Search Results

1

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR. Galligan JJ, et al. Among authors: backos ds. J Toxicol. 2012;2012:207594. doi: 10.1155/2012/207594. Epub 2012 Jul 5. J Toxicol. 2012. PMID: 22829816 Free PMC article.

2

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.

Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, Kavanagh TJ. Franklin CC, et al. Among authors: backos ds. Mol Aspects Med. 2009 Feb-Apr;30(1-2):86-98. doi: 10.1016/j.mam.2008.08.009. Epub 2008 Sep 6. Mol Aspects Med. 2009. PMID: 18812186 Free PMC article. Review.

3

Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity.

Backos DS, Brocker CN, Franklin CC. Backos DS, et al. Toxicol Appl Pharmacol. 2010 Feb 15;243(1):35-45. doi: 10.1016/j.taap.2009.11.010. Epub 2009 Nov 13. Toxicol Appl Pharmacol. 2010. PMID: 19914271 Free PMC article.

4

Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal.

Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC. Backos DS, et al. Free Radic Biol Med. 2011 Jan 1;50(1):14-26. doi: 10.1016/j.freeradbiomed.2010.10.694. Epub 2010 Oct 21. Free Radic Biol Med. 2011. PMID: 20970495 Free PMC article.

5

2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways.

Kachadourian R, Pugazhenthi S, Velmurugan K, Backos DS, Franklin CC, McCord JM, Day BJ. Kachadourian R, et al. Among authors: backos ds. Free Radic Biol Med. 2011 Sep 15;51(6):1146-54. doi: 10.1016/j.freeradbiomed.2011.05.041. Epub 2011 Jun 13. Free Radic Biol Med. 2011. PMID: 21712085 Free PMC article.

6

The role of glutathione in brain tumor drug resistance.

Backos DS, Franklin CC, Reigan P. Backos DS, et al. Biochem Pharmacol. 2012 Apr 15;83(8):1005-12. doi: 10.1016/j.bcp.2011.11.016. Epub 2011 Nov 28. Biochem Pharmacol. 2012. PMID: 22138445 Review.

7

Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.

Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P. Backos DS, et al. Neurochem Res. 2013 Sep;38(9):1838-49. doi: 10.1007/s11064-013-1090-4. Epub 2013 Jun 7. Neurochem Res. 2013. PMID: 23743623

8

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR. Shearn CT, et al. Among authors: backos ds. Free Radic Biol Med. 2013 Dec;65:680-692. doi: 10.1016/j.freeradbiomed.2013.07.011. Epub 2013 Jul 17. Free Radic Biol Med. 2013. PMID: 23872024 Free PMC article.

9

Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.

Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR. Shearn CT, et al. Among authors: backos ds. J Biol Chem. 2014 May 30;289(22):15449-62. doi: 10.1074/jbc.M113.543942. Epub 2014 Apr 10. J Biol Chem. 2014. PMID: 24722988 Free PMC article.

10

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR. Galligan JJ, et al. Among authors: backos ds. Free Radic Biol Med. 2014 Aug;73:411-20. doi: 10.1016/j.freeradbiomed.2014.06.002. Epub 2014 Jun 9. Free Radic Biol Med. 2014. PMID: 24924946 Free PMC article.

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