Mittapalli RK - Search Results

1

Active efflux of Dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly targeted agents.

Agarwal S, Mittapalli RK, Zellmer DM, Gallardo JL, Donelson R, Seiler C, Decker SA, Santacruz KS, Pokorny JL, Sarkaria JN, Elmquist WF, Ohlfest JR. Agarwal S, et al. Among authors: mittapalli rk. Mol Cancer Ther. 2012 Oct;11(10):2183-92. doi: 10.1158/1535-7163.MCT-12-0552. Epub 2012 Aug 13. Mol Cancer Ther. 2012. PMID: 22891038 Free PMC article.

2

Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032).

Mittapalli RK, Vaidhyanathan S, Sane R, Elmquist WF. Mittapalli RK, et al. J Pharmacol Exp Ther. 2012 Jul;342(1):33-40. doi: 10.1124/jpet.112.192195. Epub 2012 Mar 27. J Pharmacol Exp Ther. 2012. PMID: 22454535 Free PMC article.

3

Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases.

Mittapalli RK, Vaidhyanathan S, Dudek AZ, Elmquist WF. Mittapalli RK, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. doi: 10.1124/jpet.112.201475. Epub 2012 Dec 17. J Pharmacol Exp Ther. 2013. PMID: 23249624 Free PMC article.

4

Saturable active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier leads to nonlinear distribution of elacridar to the central nervous system.

Sane R, Agarwal S, Mittapalli RK, Elmquist WF. Sane R, et al. Among authors: mittapalli rk. J Pharmacol Exp Ther. 2013 Apr;345(1):111-24. doi: 10.1124/jpet.112.199786. Epub 2013 Feb 8. J Pharmacol Exp Ther. 2013. PMID: 23397054 Free PMC article.

5

Pharmacokinetic assessment of efflux transport in sunitinib distribution to the brain.

Oberoi RK, Mittapalli RK, Elmquist WF. Oberoi RK, et al. Among authors: mittapalli rk. J Pharmacol Exp Ther. 2013 Dec;347(3):755-64. doi: 10.1124/jpet.113.208959. Epub 2013 Oct 10. J Pharmacol Exp Ther. 2013. PMID: 24113148 Free PMC article.

6

Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model.

Parrish KE, Pokorny J, Mittapalli RK, Bakken K, Sarkaria JN, Elmquist WF. Parrish KE, et al. Among authors: mittapalli rk. J Pharmacol Exp Ther. 2015 Nov;355(2):264-71. doi: 10.1124/jpet.115.228213. Epub 2015 Sep 9. J Pharmacol Exp Ther. 2015. PMID: 26354993 Free PMC article.

7

Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.

Parrish KE, Cen L, Murray J, Calligaris D, Kizilbash S, Mittapalli RK, Carlson BL, Schroeder MA, Sludden J, Boddy AV, Agar NY, Curtin NJ, Elmquist WF, Sarkaria JN. Parrish KE, et al. Among authors: mittapalli rk. Mol Cancer Ther. 2015 Dec;14(12):2735-43. doi: 10.1158/1535-7163.MCT-15-0553. Epub 2015 Oct 5. Mol Cancer Ther. 2015. PMID: 26438157 Free PMC article.

8

ABCG2 and ABCB1 Limit the Efficacy of Dasatinib in a PDGF-B-Driven Brainstem Glioma Model.

Mittapalli RK, Chung AH, Parrish KE, Crabtree D, Halvorson KG, Hu G, Elmquist WF, Becher OJ. Mittapalli RK, et al. Mol Cancer Ther. 2016 May;15(5):819-29. doi: 10.1158/1535-7163.MCT-15-0093. Epub 2016 Feb 16. Mol Cancer Ther. 2016. PMID: 26883271 Free PMC article.

9

Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice.

Agarwal S, Uchida Y, Mittapalli RK, Sane R, Terasaki T, Elmquist WF. Agarwal S, et al. Among authors: mittapalli rk. Drug Metab Dispos. 2012 Jun;40(6):1164-9. doi: 10.1124/dmd.112.044719. Epub 2012 Mar 8. Drug Metab Dispos. 2012. PMID: 22401960 Free PMC article.

10

Brain metastases from renal cell carcinoma in the era of tyrosine kinase inhibitors.

Dudek AZ, Raza A, Chi M, Singhal M, Oberoi R, Mittapalli RK, Agarwal S, Elmquist WF. Dudek AZ, et al. Among authors: mittapalli rk. Clin Genitourin Cancer. 2013 Jun;11(2):155-60. doi: 10.1016/j.clgc.2012.11.001. Epub 2012 Dec 21. Clin Genitourin Cancer. 2013. PMID: 23265925 Free PMC article.

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