Reilly TP - Search Results

1

Targeting renal glucose reabsorption for the treatment of type 2 diabetes mellitus using the SGLT2 inhibitor dapagliflozin.

Jabbour SA, Whaley JM, Tirmenstein M, Poucher SM, Reilly TP, Boulton DW, Saye J, List JF, Parikh S. Jabbour SA, et al. Among authors: reilly tp. Postgrad Med. 2012 Jul;124(4):62-73. doi: 10.3810/pgm.2012.07.2569. Postgrad Med. 2012. PMID: 22913895 Review.

2

Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus.

Whaley JM, Tirmenstein M, Reilly TP, Poucher SM, Saye J, Parikh S, List JF. Whaley JM, et al. Among authors: reilly tp. Diabetes Metab Syndr Obes. 2012;5:135-48. doi: 10.2147/DMSO.S22503. Epub 2012 Jul 23. Diabetes Metab Syndr Obes. 2012. PMID: 22923998 Free PMC article.

3

Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor.

Tirmenstein M, Dorr TE, Janovitz EB, Hagan D, Abell LM, Onorato JM, Whaley JM, Graziano MJ, Reilly TP. Tirmenstein M, et al. Among authors: reilly tp. Int J Toxicol. 2013 Sep-Oct;32(5):336-50. doi: 10.1177/1091581813505331. Epub 2013 Oct 4. Int J Toxicol. 2013. PMID: 24097127

4

Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus.

Reilly TP, Graziano MJ, Janovitz EB, Dorr TE, Fairchild C, Lee F, Chen J, Wong T, Whaley JM, Tirmenstein M. Reilly TP, et al. Diabetes Ther. 2014 Jun;5(1):73-96. doi: 10.1007/s13300-014-0053-3. Epub 2014 Jan 29. Diabetes Ther. 2014. PMID: 24474422 Free PMC article.

5

Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.

Tirmenstein M, Horvath J, Graziano M, Mangipudy R, Dorr T, Colman K, Zinker B, Kirby M, Cheng PT, Patrone L, Kozlosky J, Reilly TP, Wang V, Janovitz E. Tirmenstein M, et al. Among authors: reilly tp. Toxicol Pathol. 2015 Aug;43(6):825-37. doi: 10.1177/0192623315581020. Epub 2015 Jun 17. Toxicol Pathol. 2015. PMID: 26085543

6

Assessing Bladder Cancer Risk in Type 2 Diabetes Clinical Trials: the Dapagliflozin Drug Development Program as a 'Case Study'.

Ptaszynska A, Cohen SM, Messing EM, Reilly TP, Johnsson E, Johnsson K. Ptaszynska A, et al. Among authors: reilly tp. Diabetes Ther. 2015 Sep;6(3):357-75. doi: 10.1007/s13300-015-0128-9. Epub 2015 Sep 1. Diabetes Ther. 2015. PMID: 26323372 Free PMC article.

7

Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential.

LeCureux L, Cheng CS, Herbst J, Reilly TP, Lehman-McKeeman L, Otieno M. LeCureux L, et al. Among authors: reilly tp. Toxicol In Vitro. 2011 Dec;25(8):1934-43. doi: 10.1016/j.tiv.2011.06.017. Epub 2011 Jul 13. Toxicol In Vitro. 2011. PMID: 21767630

8

Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.

Chadwick KD, Fletcher AM, Parrula MC, Bonner-Weir S, Mangipudy RS, Janovitz E, Graziano MJ, Roy D, Reilly TP. Chadwick KD, et al. Among authors: reilly tp. Diabetes. 2014 Apr;63(4):1303-14. doi: 10.2337/db13-1268. Epub 2013 Nov 12. Diabetes. 2014. PMID: 24222349

9

The glucagon-like peptide-1-based therapeutics exenatide and saxagliptin did not cause detrimental effects on the pancreas in mice, rats, dogs and monkeys.

Roy D, Chadwick KD, Tatarkiewicz K, LaCerte C, Bergholm AM, Brodie T, Mangipudy RS, Parkes D, Graziano MJ, Reilly TP. Roy D, et al. Among authors: reilly tp. Diabetes Obes Metab. 2014 Oct;16(10):910-21. doi: 10.1111/dom.12294. Epub 2014 Apr 27. Diabetes Obes Metab. 2014. PMID: 24666399

10

Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses.

Caetano MS, Younes AI, Barsoumian HB, Quigley M, Menon H, Gao C, Spires T, Reilly TP, Cadena AP, Cushman TR, Schoenhals JE, Li A, Nguyen QN, Cortez MA, Welsh JW. Caetano MS, et al. Among authors: reilly tp. Clin Cancer Res. 2019 Dec 15;25(24):7576-7584. doi: 10.1158/1078-0432.CCR-19-0795. Epub 2019 Sep 20. Clin Cancer Res. 2019. PMID: 31540976 Free PMC article.

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