Whaley JM - Search Results

1

Targeting renal glucose reabsorption for the treatment of type 2 diabetes mellitus using the SGLT2 inhibitor dapagliflozin.

Jabbour SA, Whaley JM, Tirmenstein M, Poucher SM, Reilly TP, Boulton DW, Saye J, List JF, Parikh S. Jabbour SA, et al. Among authors: whaley jm. Postgrad Med. 2012 Jul;124(4):62-73. doi: 10.3810/pgm.2012.07.2569. Postgrad Med. 2012. PMID: 22913895 Review.

2

Inhibition of SGLT2: a novel strategy for treatment of type 2 diabetes mellitus.

Pfister M, Whaley JM, Zhang L, List JF. Pfister M, et al. Among authors: whaley jm. Clin Pharmacol Ther. 2011 Apr;89(4):621-5. doi: 10.1038/clpt.2011.16. Epub 2011 Feb 23. Clin Pharmacol Ther. 2011. PMID: 21346749 Review. No abstract available.

3

Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans.

List JF, Whaley JM. List JF, et al. Among authors: whaley jm. Kidney Int Suppl. 2011 Mar;(120):S20-7. doi: 10.1038/ki.2010.512. Kidney Int Suppl. 2011. PMID: 21358698 Free article. Review.

4

Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus.

Whaley JM, Tirmenstein M, Reilly TP, Poucher SM, Saye J, Parikh S, List JF. Whaley JM, et al. Diabetes Metab Syndr Obes. 2012;5:135-48. doi: 10.2147/DMSO.S22503. Epub 2012 Jul 23. Diabetes Metab Syndr Obes. 2012. PMID: 22923998 Free PMC article.

5

Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor.

Tirmenstein M, Dorr TE, Janovitz EB, Hagan D, Abell LM, Onorato JM, Whaley JM, Graziano MJ, Reilly TP. Tirmenstein M, et al. Among authors: whaley jm. Int J Toxicol. 2013 Sep-Oct;32(5):336-50. doi: 10.1177/1091581813505331. Epub 2013 Oct 4. Int J Toxicol. 2013. PMID: 24097127

6

The novel sodium glucose transporter 2 inhibitor dapagliflozin sustains pancreatic function and preserves islet morphology in obese, diabetic rats.

Macdonald FR, Peel JE, Jones HB, Mayers RM, Westgate L, Whaley JM, Poucher SM. Macdonald FR, et al. Among authors: whaley jm. Diabetes Obes Metab. 2010 Nov;12(11):1004-12. doi: 10.1111/j.1463-1326.2010.01291.x. Diabetes Obes Metab. 2010. PMID: 20880347

7

Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus.

Reilly TP, Graziano MJ, Janovitz EB, Dorr TE, Fairchild C, Lee F, Chen J, Wong T, Whaley JM, Tirmenstein M. Reilly TP, et al. Among authors: whaley jm. Diabetes Ther. 2014 Jun;5(1):73-96. doi: 10.1007/s13300-014-0053-3. Epub 2014 Jan 29. Diabetes Ther. 2014. PMID: 24474422 Free PMC article.

8

Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats.

Han S, Hagan DL, Taylor JR, Xin L, Meng W, Biller SA, Wetterau JR, Washburn WN, Whaley JM. Han S, et al. Among authors: whaley jm. Diabetes. 2008 Jun;57(6):1723-9. doi: 10.2337/db07-1472. Epub 2008 Mar 20. Diabetes. 2008. PMID: 18356408

9

Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.

Meng W, Ellsworth BA, Nirschl AA, McCann PJ, Patel M, Girotra RN, Wu G, Sher PM, Morrison EP, Biller SA, Zahler R, Deshpande PP, Pullockaran A, Hagan DL, Morgan N, Taylor JR, Obermeier MT, Humphreys WG, Khanna A, Discenza L, Robertson JG, Wang A, Han S, Wetterau JR, Janovitz EB, Flint OP, Whaley JM, Washburn WN. Meng W, et al. Among authors: whaley jm. J Med Chem. 2008 Mar 13;51(5):1145-9. doi: 10.1021/jm701272q. Epub 2008 Feb 9. J Med Chem. 2008. PMID: 18260618

10

SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic β-cell death in genetically obese mice.

Jurczak MJ, Saini S, Ioja S, Costa DK, Udeh N, Zhao X, Whaley JM, Kibbey RG. Jurczak MJ, et al. Among authors: whaley jm. Islets. 2018;10(5):181-189. doi: 10.1080/19382014.2018.1503027. Epub 2018 Aug 17. Islets. 2018. PMID: 30118626 Free PMC article.

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