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RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.
Anton PA, Cranston RD, Kashuba A, Hendrix CW, Bumpus NN, Richardson-Harman N, Elliott J, Janocko L, Khanukhova E, Dennis R, Cumberland WG, Ju C, Carballo-Diéguez A, Mauck C, McGowan I. Anton PA, et al. AIDS Res Hum Retroviruses. 2012 Nov;28(11):1412-21. doi: 10.1089/aid.2012.0262. Epub 2012 Oct 9. AIDS Res Hum Retroviruses. 2012. PMID: 22943559 Free PMC article. Clinical Trial.
First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy.
Anton PA, Saunders T, Elliott J, Khanukhova E, Dennis R, Adler A, Cortina G, Tanner K, Boscardin J, Cumberland WG, Zhou Y, Ventuneac A, Carballo-Diéguez A, Rabe L, McCormick T, Gabelnick H, Mauck C, McGowan I. Anton PA, et al. PLoS One. 2011;6(9):e23243. doi: 10.1371/journal.pone.0023243. Epub 2011 Sep 28. PLoS One. 2011. PMID: 21969851 Free PMC article. Clinical Trial.
Isoosmolar enemas demonstrate preferential gastrointestinal distribution, safety, and acceptability compared with hyperosmolar and hypoosmolar enemas as a potential delivery vehicle for rectal microbicides.
Leyva FJ, Bakshi RP, Fuchs EJ, Li L, Caffo BS, Goldsmith AJ, Ventuneac A, Carballo-Diéguez A, Du Y, Leal JP, Lee LA, Torbenson MS, Hendrix CW. Leyva FJ, et al. AIDS Res Hum Retroviruses. 2013 Nov;29(11):1487-95. doi: 10.1089/aid.2013.0189. Epub 2013 Aug 24. AIDS Res Hum Retroviruses. 2013. PMID: 23885722 Free PMC article. Clinical Trial.
172 results