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A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation.
Rao S, Lembo AJ, Shiff SJ, Lavins BJ, Currie MG, Jia XD, Shi K, MacDougall JE, Shao JZ, Eng P, Fox SM, Schneier HA, Kurtz CB, Johnston JM. Rao S, et al. Among authors: fox sm. Am J Gastroenterol. 2012 Nov;107(11):1714-24; quiz p.1725. doi: 10.1038/ajg.2012.255. Am J Gastroenterol. 2012. PMID: 22986440 Free PMC article. Clinical Trial.
Two randomized trials of linaclotide for chronic constipation.
Lembo AJ, Schneier HA, Shiff SJ, Kurtz CB, MacDougall JE, Jia XD, Shao JZ, Lavins BJ, Currie MG, Fitch DA, Jeglinski BI, Eng P, Fox SM, Johnston JM. Lembo AJ, et al. Among authors: fox sm. N Engl J Med. 2011 Aug 11;365(6):527-36. doi: 10.1056/NEJMoa1010863. N Engl J Med. 2011. PMID: 21830967 Free article. Clinical Trial.
Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial.
Lacy BE, Schey R, Shiff SJ, Lavins BJ, Fox SM, Jia XD, Blakesley RE, Hao X, Cronin JA, Currie MG, Kurtz CB, Johnston JM, Lembo AJ. Lacy BE, et al. Among authors: fox sm. PLoS One. 2015 Jul 29;10(7):e0134349. doi: 10.1371/journal.pone.0134349. eCollection 2015. PLoS One. 2015. PMID: 26222318 Free PMC article. Clinical Trial.
Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial.
Schoenfeld P, Lacy BE, Chey WD, Lembo AJ, Kurtz CB, Reasner DS, Bochenek W, Tripp K, Currie MG, Fox SM, Blakesley RE, OʼDea CR, Omniewski ND, Hall ML. Schoenfeld P, et al. Among authors: fox sm. Am J Gastroenterol. 2018 Jan;113(1):105-114. doi: 10.1038/ajg.2017.230. Epub 2017 Aug 22. Am J Gastroenterol. 2018. PMID: 29091082 Free PMC article. Clinical Trial.
Safety and tolerability of linaclotide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: pooled Phase 3 analysis.
Nee JW, Johnston JM, Shea EP, Walls CE, Tripp K, Shiff S, Fox SM, Bochenek W, Weissman D, Currie MG, Lembo AJ. Nee JW, et al. Among authors: fox sm. Expert Rev Gastroenterol Hepatol. 2019 Apr;13(4):397-406. doi: 10.1080/17474124.2019.1575203. Epub 2019 Feb 18. Expert Rev Gastroenterol Hepatol. 2019. PMID: 30791771
Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System.
Chang L, Lacy BE, Moshiree B, Kassebaum A, Abel JL, Hanlon J, Bartolini W, Boinpally R, Bochenek W, Fox SM, Mallick M, Tripp K, Omniewski N, Shea E, Borgstein N. Chang L, et al. Among authors: fox sm. Am J Gastroenterol. 2021 Sep 1;116(9):1929-1937. doi: 10.14309/ajg.0000000000001334. Am J Gastroenterol. 2021. PMID: 34465695 Clinical Trial.
Optimizing Advanced Imaging of the Pediatric Patient in the Emergency Department: Technical Report.
Marin JR, Lyons TW, Claudius I, Fallat ME, Aquino M, Ruttan T, Daugherty RJ; AMERICAN ACADEMY OF PEDIATRICS Committee on Pediatric Emergency Medicine, Section on Radiology; AMERICAN COLLEGE OF RADIOLOGY; AMERICAN COLLEGE OF EMERGENCY PHYSICIANS Pediatric Emergency Medicine Committee. Marin JR, et al. Pediatrics. 2024 Jul 1;154(1):e2024066855. doi: 10.1542/peds.2024-066855. Pediatrics. 2024. PMID: 38932719
Optimizing Advanced Imaging of the Pediatric Patient in the Emergency Department: Policy Statement.
Marin JR, Lyons TW, Claudius I, Fallat ME, Aquino M, Ruttan T, Daugherty RJ; AMERICAN ACADEMY OF PEDIATRICS Committee on Pediatric Emergency Medicine, Section on Radiology; AMERICAN COLLEGE OF RADIOLOGY; AMERICAN COLLEGE OF EMERGENCY PHYSICIANS Pediatric Emergency Medicine Committee. Marin JR, et al. Pediatrics. 2024 Jul 1;154(1):e2024066854. doi: 10.1542/peds.2024-066854. Pediatrics. 2024. PMID: 38932710
123 results