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A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance.
Vandenbark AA, Meza-Romero R, Benedek G, Andrew S, Huan J, Chou YK, Buenafe AC, Dahan R, Reiter Y, Mooney JL, Offner H, Burrows GG. Vandenbark AA, et al. Among authors: burrows gg. J Autoimmun. 2013 Feb;40:96-110. doi: 10.1016/j.jaut.2012.08.004. Epub 2012 Sep 29. J Autoimmun. 2013. PMID: 23026773 Free PMC article.
A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.
Sinha S, Subramanian S, Proctor TM, Kaler LJ, Grafe M, Dahan R, Huan J, Vandenbark AA, Burrows GG, Offner H. Sinha S, et al. Among authors: burrows gg. J Neurosci. 2007 Nov 14;27(46):12531-9. doi: 10.1523/JNEUROSCI.3599-07.2007. J Neurosci. 2007. PMID: 18003831 Free PMC article.
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.
Sinha S, Miller L, Subramanian S, McCarty OJ, Proctor T, Meza-Romero R, Huan J, Burrows GG, Vandenbark AA, Offner H. Sinha S, et al. Among authors: burrows gg. J Neuroimmunol. 2010 Aug 25;225(1-2):52-61. doi: 10.1016/j.jneuroim.2010.04.013. Epub 2010 May 23. J Neuroimmunol. 2010. PMID: 20546940 Free PMC article.
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects.
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows GG, Bourdette D, Offner H, Bucala R, Vandenbark AA. Benedek G, et al. Among authors: burrows gg. Eur J Immunol. 2013 May;43(5):1309-21. doi: 10.1002/eji.201243162. Epub 2013 Apr 10. Eur J Immunol. 2013. PMID: 23576302 Free PMC article.
61 results