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A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance.
Vandenbark AA, Meza-Romero R, Benedek G, Andrew S, Huan J, Chou YK, Buenafe AC, Dahan R, Reiter Y, Mooney JL, Offner H, Burrows GG. Vandenbark AA, et al. Among authors: mooney jl. J Autoimmun. 2013 Feb;40:96-110. doi: 10.1016/j.jaut.2012.08.004. Epub 2012 Sep 29. J Autoimmun. 2013. PMID: 23026773 Free PMC article.
Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease.
Huan J, Meza-Romero R, Mooney JL, Vandenbark AA, Offner H, Burrows GG. Huan J, et al. Among authors: mooney jl. Mucosal Immunol. 2011 Jan;4(1):112-20. doi: 10.1038/mi.2010.44. Epub 2010 Aug 25. Mucosal Immunol. 2011. PMID: 20736999 Free PMC article.
Rationally designed mutations convert complexes of human recombinant T cell receptor ligands into monomers that retain biological activity.
Huan JY, Meza-Romero R, Mooney JL, Chou YK, Edwards DM, Rich C, Link JM, Vandenbark AA, Bourdette DN, Bächinger HP, Burrows GG. Huan JY, et al. Among authors: mooney jl. J Chem Technol Biotechnol. 2005 Jan;80(1):2-12. doi: 10.1002/jctb.1086. Epub 2004 Oct 12. J Chem Technol Biotechnol. 2005. PMID: 22973070 Free PMC article.
34 results