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The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. Causey CP, et al. Among authors: hofseth lj. J Med Chem. 2011 Oct 13;54(19):6919-35. doi: 10.1021/jm2008985. Epub 2011 Sep 16. J Med Chem. 2011. PMID: 21882827 Free PMC article.
Inhibiting protein arginine deiminases has antioxidant consequences.
Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ. Witalison EE, et al. Among authors: hofseth lj, hofseth ab. J Pharmacol Exp Ther. 2015 Apr;353(1):64-70. doi: 10.1124/jpet.115.222745. Epub 2015 Jan 29. J Pharmacol Exp Ther. 2015. PMID: 25635139 Free PMC article.
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ. Chumanevich AA, et al. Among authors: hofseth lj. Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G929-38. doi: 10.1152/ajpgi.00435.2010. Epub 2011 Mar 17. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21415415 Free PMC article.
Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties.
Chumanevich AA, Witalison EE, Chaparala A, Chumanevich A, Nagarkatti P, Nagarkatti M, Hofseth LJ. Chumanevich AA, et al. Among authors: hofseth lj. Oncotarget. 2016 Aug 16;7(33):52928-52939. doi: 10.18632/oncotarget.10608. Oncotarget. 2016. PMID: 27447967 Free PMC article.
97 results