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Thalidomide maintenance therapy maturates the T cell compartment and compromises antigen-specific antitumor immunity in patients with multiple myeloma.
Herth I, Witzens-Harig M, Beckhove P, Hose D, Meissner T, Neuber B, Engelhardt M, Haas J, Neben K, Ho AD, Klein B, Goldschmidt H, Hundemer M. Herth I, et al. Among authors: engelhardt m. Exp Hematol. 2013 Mar;41(3):231-40. doi: 10.1016/j.exphem.2012.10.018. Epub 2012 Nov 8. Exp Hematol. 2013. PMID: 23142220 Free article. Clinical Trial.
IL-10 inducible CD8+ regulatory T-cells are enriched in patients with multiple myeloma and impact the generation of antigen-specific T-cells.
Plaumann J, Engelhardt M, Awwad MHS, Echchannaoui H, Amman E, Raab MS, Hillengass J, Halama N, Neuber B, Müller-Tidow C, Goldschmidt H, Hundemer M. Plaumann J, et al. Among authors: engelhardt m. Cancer Immunol Immunother. 2018 Nov;67(11):1695-1707. doi: 10.1007/s00262-018-2230-0. Epub 2018 Aug 20. Cancer Immunol Immunother. 2018. PMID: 30128739 Free PMC article.
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion.
Munder M, Engelhardt M, Knies D, Medenhoff S, Wabnitz G, Luckner-Minden C, Feldmeyer N, Voss RH, Kropf P, Müller I, Conradi R, Samstag Y, Theobald M, Ho AD, Goldschmidt H, Hundemer M. Munder M, et al. Among authors: engelhardt m. PLoS One. 2013 May 23;8(5):e63521. doi: 10.1371/journal.pone.0063521. Print 2013. PLoS One. 2013. PMID: 23717444 Free PMC article.
Lenalidomide enhances myeloma-specific T-cell responses in vivo and in vitro.
Krämer I, Engelhardt M, Fichtner S, Neuber B, Medenhoff S, Bertsch U, Hillengass J, Raab MS, Hose D, Ho AD, Goldschmidt H, Hundemer M. Krämer I, et al. Among authors: engelhardt m. Oncoimmunology. 2016 Feb 18;5(5):e1139662. doi: 10.1080/2162402X.2016.1139662. eCollection 2016 May. Oncoimmunology. 2016. PMID: 27467960 Free PMC article.
Lenalidomide overcomes the immunosuppression of regulatory CD8+CD28- T-cells.
Neuber B, Dai J, Waraich WA, Awwad MHS, Engelhardt M, Schmitt M, Medenhoff S, Witzens-Harig M, Ho AD, Goldschmidt H, Hundemer M. Neuber B, et al. Among authors: engelhardt m. Oncotarget. 2017 Oct 5;8(58):98200-98214. doi: 10.18632/oncotarget.21516. eCollection 2017 Nov 17. Oncotarget. 2017. PMID: 29228683 Free PMC article.
634 results