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Page 1
Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.
Ziauddeen H, Chamberlain SR, Nathan PJ, Koch A, Maltby K, Bush M, Tao WX, Napolitano A, Skeggs AL, Brooke AC, Cheke L, Clayton NS, Sadaf Farooqi I, O'Rahilly S, Waterworth D, Song K, Hosking L, Richards DB, Fletcher PC, Bullmore ET. Ziauddeen H, et al. Among authors: skeggs al. Mol Psychiatry. 2013 Dec;18(12):1287-93. doi: 10.1038/mp.2012.154. Epub 2012 Nov 13. Mol Psychiatry. 2013. PMID: 23147384 Free PMC article. Clinical Trial.
Opioid receptor modulation of hedonic taste preference and food intake: a single-dose safety, pharmacokinetic, and pharmacodynamic investigation with GSK1521498, a novel μ-opioid receptor inverse agonist.
Nathan PJ, O'Neill BV, Bush MA, Koch A, Tao WX, Maltby K, Napolitano A, Brooke AC, Skeggs AL, Herman CS, Larkin AL, Ignar DM, Richards DB, Williams PM, Bullmore ET. Nathan PJ, et al. Among authors: skeggs al. J Clin Pharmacol. 2012 Apr;52(4):464-74. doi: 10.1177/0091270011399577. Epub 2011 May 24. J Clin Pharmacol. 2012. PMID: 21610207 Clinical Trial.
Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.
Cambridge VC, Ziauddeen H, Nathan PJ, Subramaniam N, Dodds C, Chamberlain SR, Koch A, Maltby K, Skeggs AL, Napolitano A, Farooqi IS, Bullmore ET, Fletcher PC. Cambridge VC, et al. Among authors: skeggs al. Biol Psychiatry. 2013 May 1;73(9):887-94. doi: 10.1016/j.biopsych.2012.10.022. Epub 2012 Dec 14. Biol Psychiatry. 2013. PMID: 23245760 Free PMC article. Clinical Trial.
Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.
Fletcher PC, Napolitano A, Skeggs A, Miller SR, Delafont B, Cambridge VC, de Wit S, Nathan PJ, Brooke A, O'Rahilly S, Farooqi IS, Bullmore ET. Fletcher PC, et al. J Neurosci. 2010 Oct 27;30(43):14346-55. doi: 10.1523/JNEUROSCI.3323-10.2010. J Neurosci. 2010. PMID: 20980590 Free PMC article. Clinical Trial.
Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations.
McKeever T, Mortimer K, Wilson A, Walker S, Brightling C, Skeggs A, Pavord I, Price D, Duley L, Thomas M, Bradshaw L, Higgins B, Haydock R, Mitchell E, Devereux G, Harrison T. McKeever T, et al. N Engl J Med. 2018 Mar 8;378(10):902-910. doi: 10.1056/NEJMoa1714257. Epub 2018 Mar 3. N Engl J Med. 2018. PMID: 29504499 Free article. Clinical Trial.
FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations.
Skeggs A, McKeever T, Duley L, Mitchell E, Bradshaw L, Mortimer K, Walker S, Parrott S, Wilson A, Pavord I, Brightling C, Thomas M, Price D, Devereux G, Higgins B, Harrison T, Haydock R. Skeggs A, et al. Trials. 2016 Oct 13;17(1):499. doi: 10.1186/s13063-016-1608-6. Trials. 2016. PMID: 27737713 Free PMC article. Clinical Trial.
Comparing an optimised physiotherapy treatment package with usual physiotherapy care for people with tennis elbow - protocol for the OPTimisE pilot and feasibility randomised controlled trial.
Bateman M, Saunders B, Littlewood C, Davis D, Beckhelling J, Cooper K, Skeggs A, Foster NE, Vicenzino B, Hill JC. Bateman M, et al. Pilot Feasibility Stud. 2022 Aug 11;8(1):178. doi: 10.1186/s40814-022-01132-x. Pilot Feasibility Stud. 2022. PMID: 35953842 Free PMC article.