Kakuda S - Search Results

1

Synthesis of 14-epi-2α-hydroxypropoxy-1α,25-dihydroxy-19-nortachysterol and its hVDR binding.

Sawada D, Tsukuda Y, Saito H, Takagi K, Kakuda S, Takimoto-Kamimura M, Ochiai E, Takenouchi K, Kittaka A. Sawada D, et al. Among authors: kakuda s. J Steroid Biochem Mol Biol. 2013 Jul;136:27-9. doi: 10.1016/j.jsbmb.2012.11.014. Epub 2012 Dec 14. J Steroid Biochem Mol Biol. 2013. PMID: 23246987 Review.

2

Structure of the ligand-binding domain of rat VDR in complex with the nonsecosteroidal vitamin D3 analogue YR301.

Kakuda S, Okada K, Eguchi H, Takenouchi K, Hakamata W, Kurihara M, Takimoto-Kamimura M. Kakuda S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):970-3. doi: 10.1107/S1744309108026754. Epub 2008 Oct 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18997319 Free PMC article.

3

Structural basis of the histidine-mediated vitamin D receptor agonistic and antagonistic mechanisms of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone.

Kakuda S, Ishizuka S, Eguchi H, Mizwicki MT, Norman AW, Takimoto-Kamimura M. Kakuda S, et al. Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):918-26. doi: 10.1107/S0907444910020810. Epub 2010 Jul 10. Acta Crystallogr D Biol Crystallogr. 2010. PMID: 20693691

4

Development of 14-epi-19-nortachysterol and its unprecedented binding configuration for the human vitamin D receptor.

Sawada D, Tsukuda Y, Saito H, Kakuda S, Takimoto-Kamimura M, Ochiai E, Takenouchi K, Kittaka A. Sawada D, et al. Among authors: kakuda s. J Am Chem Soc. 2011 May 11;133(18):7215-21. doi: 10.1021/ja201481j. Epub 2011 Apr 18. J Am Chem Soc. 2011. PMID: 21500802

5

New C15-substituted active vitamin D3.

Shindo K, Kumagai G, Takano M, Sawada D, Saito N, Saito H, Kakuda S, Takagi K, Ochiai E, Horie K, Takimoto-Kamimura M, Ishizuka S, Takenouchi K, Kittaka A. Shindo K, et al. Among authors: kakuda s. Org Lett. 2011 Jun 3;13(11):2852-5. doi: 10.1021/ol200828s. Epub 2011 May 3. Org Lett. 2011. PMID: 21539305

6

Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands.

Demizu Y, Takahashi T, Kaneko F, Sato Y, Okuda H, Ochiai E, Horie K, Takagi K, Kakuda S, Takimoto-Kamimura M, Kurihara M. Demizu Y, et al. Among authors: kakuda s. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6104-7. doi: 10.1016/j.bmcl.2011.08.047. Epub 2011 Aug 17. Bioorg Med Chem Lett. 2011. PMID: 21889334

7

C15-functionalized 16-ene-1α,25-dihydroxyvitamin D3 is a new vitamin D analog with unique biological properties.

Kumagai G, Takano M, Shindo K, Sawada D, Saito N, Saito H, Kakuda S, Takagi K, Takimoto-Kamimura M, Takenouchi K, Chen TC, Kittaka A. Kumagai G, et al. Among authors: kakuda s. Anticancer Res. 2012 Jan;32(1):311-7. Anticancer Res. 2012. PMID: 22213321

8

The difference between 14-epi-previtamin D3 and 14-epi-19-norprevitamin D3: their synthesis and binding affinity for human VDR.

Sawada D, Katayama T, Tsukuda Y, Saito N, Saito H, Kakuda S, Takimoto-Kamimura M, Takenouchi K, Kittaka A. Sawada D, et al. Among authors: kakuda s. Anticancer Res. 2012 Jan;32(1):319-26. Anticancer Res. 2012. PMID: 22213322

9

Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone.

Saito H, Takagi K, Horie K, Kakuda S, Takimoto-Kamimura M, Ochiai E, Chida T, Harada Y, Takenouchi K, Kittaka A. Saito H, et al. Among authors: kakuda s. J Steroid Biochem Mol Biol. 2013 Jul;136:3-8. doi: 10.1016/j.jsbmb.2013.02.004. Epub 2013 Feb 13. J Steroid Biochem Mol Biol. 2013. PMID: 23416104 Review.

10

Design and synthesis of 2α-(tetrazolylethyl)-1α,25-dihydroxyvitamin D3 as a high affinity ligand for vitamin D receptor.

Matsuo M, Hasegawa A, Takano M, Saito H, Kakuda S, Takagi K, Ochiai E, Horie K, Takimoto-Kamimura M, Takenouchi K, Sawada D, Kittaka A. Matsuo M, et al. Among authors: kakuda s. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:201-3. doi: 10.1016/j.jsbmb.2013.09.001. Epub 2013 Sep 10. J Steroid Biochem Mol Biol. 2014. PMID: 24036313 Review.

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