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Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.
Galea GL, Meakin LB, Sugiyama T, Zebda N, Sunters A, Taipaleenmaki H, Stein GS, van Wijnen AJ, Lanyon LE, Price JS. Galea GL, et al. Among authors: lanyon le. J Biol Chem. 2013 Mar 29;288(13):9035-48. doi: 10.1074/jbc.M112.405456. Epub 2013 Jan 29. J Biol Chem. 2013. PMID: 23362266 Free PMC article.
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.
Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, Price JS. Sunters A, et al. Among authors: lanyon le. J Biol Chem. 2010 Mar 19;285(12):8743-58. doi: 10.1074/jbc.M109.027086. Epub 2009 Dec 30. J Biol Chem. 2010. PMID: 20042609 Free PMC article.
Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent.
Zaman G, Sunters A, Galea GL, Javaheri B, Saxon LK, Moustafa A, Armstrong VJ, Price JS, Lanyon LE. Zaman G, et al. Among authors: lanyon le. J Biol Chem. 2012 Feb 3;287(6):3946-62. doi: 10.1074/jbc.M111.252742. Epub 2011 Nov 2. J Biol Chem. 2012. PMID: 22049075 Free PMC article.
161 results